Varying Presentations of Multisystem Inflammatory Syndrome Temporarily Associated with COVID-19

Table 2

Definition of MIS-C by the WHO [7].

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(1) Children and adolescents 0–19 years of age with fever >3 days

(2) AND two of the following:

 (i) Rash or bilateral nonpurulent conjunctivitis or mucocutaneous inflammation signs (oral, hands, or feet)

 (ii) Hypotension or shock

 (iii) Features of myocardial dysfunction, pericarditis, valvulitis, or coronary abnormalities (including ECHO findings or elevated troponin/NT-proBNP)

 (iv) Evidence of coagulopathy (by PT, PTT, and elevated D-dimers)

 (v) Acute gastrointestinal problems (diarrhoea, vomiting, or abdominal pain)

(3) AND elevated markers of inflammation such as ESR, C-reactive protein, or procalcitonin

(4) AND no other obvious microbial cause of inflammation, including bacterial sepsis and staphylococcal or streptococcal shock syndromes

(5) AND evidence of COVID-19 (RT-PCR, antigen test, or serology positive) or likely contact with patients with COVID-19

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