Case Reports in Pediatrics / 2020 / Article / Tab 1

Case Report

Vaginal Bleeding in an Infant with Extreme Prematurity

Table 1

Summary on reported cases of preterm female infants presenting with uterine bleeding.

Author (year)Gestation (weeks)Corrected age on presentationClinical symptomsLH (IU/L)FSH (IU/L)Estradiol (pmol/L)Management and outcome

Aafke et al. (2013)255 weeksVaginal bleeding, breast buds6.94.5964Treated with GnRH analog for 15 months, no recurrence of pubertal development after cessation of treatment
Maria et al. (2016)252.25 monthsVaginal bleeding, breast buds, facial acne, right ovarian cyst25.7253Conservative, breast buds decreased in size, and LH and FSH returned to prepubertal levels at 5.5 mo corrected
Maria et al. (2016)242.5 monthsVaginal bleeding, breast buds, facial acne, left ovarian cyst115.7451Conservative, breast buds decreased in size, and LH and FSH returned to prepubertal levels at 6.5 mo corrected
Gisselle et al. (2017)243.5 monthsVaginal bleeding, breast buds, estrogenized vaginal mucosa, and enlarged labia minora1.33.1458Treated with GnRH analog, outcome not stated in the article

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.