Case Report

Treatment of a Prader-Willi Patient with Recurrent Catatonia

Table 1

ECT treatment course.

ECT MedicationsEnergy/chargeMotor/EEG responseClinical response

1Ziprasidone 60 mg twice daily, lamotrigine 200 mg before bed, and lorazepam 1 mg three times daily 25% bifrontal
128.9 mc
1 sec motor/36 sec EEGImproved verbal response for 30 min and then back to catatonic state. Throughout the day, patient became more verbal and coherent and even expressed humor.

2Identical regimen as time point 140% bifrontal
204.2 mc
10 sec motor/40 sec EEGLess interactive, disoriented, with repetitive movements.

3Identical regimen as time point 150%/75% bifrontal1
258.7 mc
1 sec motor/7 sec EEG
5 sec motor/48 sec EEG
Less energetic, increasingly drowsy, minimal interaction, decreased sleep, and pacing hallways.

4Ziprasidone 60 mg twice daily,
lamotrigine 150 mg before bed, and lorazepam 0.5 mg three times daily
75% bifrontal
377.4 mc
33 sec motor/56 sec EEGVery drowsy, psychomotor retardation, decreased sleep, waxy flexibility, and increased speech latency.

5Ziprasidone 80 mg twice daily,
lamotrigine 150 mg before bed, and lorazepam 0.5 mg three times daily
75% bifrontal
376.1 mc
21 sec motor/29 sec EEGMuch more engaged, aware, conversational, and oriented to situation.

6Ziprasidone 80 mg twice a day,
lamotrigine 150 mg before bed (held before ECT), and lorazepam 0.5 twice daily
100% bifrontal
502.4 mc
19 sec motor/34 sec EEGWaxing/waning mutism, repetitive movements, and psychomotor retardation.

7Ziprasidone 80 mg twice daily,
lamotrigine 150 mg before bed (held before ECT),
and d/c lorazepam
100% bifrontal
503.2 mc
19 sec motor/34 sec EEGImproved but still with low energy and very drowsy.

8Ziprasidone 40 mg am/80 mg pm, lamotrigine 150 mg before bed100% bitemporal
502.9 mc
11 sec motor/56 sec EEGRegaining energy, more engaged, with improved affect.

Morning dose of lorazepam was held in mornings of ECT for better seizure response.
1Treatment required two stimuli due to poor motor response.