Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Psychiatry
Volume 2015, Article ID 815673, 3 pages
http://dx.doi.org/10.1155/2015/815673
Case Report

Robust and Sustained Effect of Ketamine Infusions Coadministered with Conventional Antidepressants in a Patient with Refractory Major Depression

1Psychiatry Service, Hospital Universitario Ramón y Cajal, Universidad de Alcalá, CIBERSAM, IRYCIS, Carretera Colmenar km. 9.1, 28034 Madrid, Spain
2Psychiatry Service, Hospital Universitario del Sureste, Universidad Rey Juan Carlos, Ronda del Sur 10, 28500 Madrid, Spain
3Anaesthesiology Service, Hospital Universitario del Sureste, Universidad Rey Juan Carlos, Ronda del Sur 10, 28500 Madrid, Spain

Received 22 December 2014; Accepted 23 February 2015

Academic Editor: Thomas Frodl

Copyright © 2015 José Manuel Montes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Antidepressant treatments show low capacity to achieve full clinical remissions. Electroconvulsive therapy is an alternative treatment which has been shown to be more effective but it is not well tolerated and there are concerns regarding its safety. We present the case of a patient with resistant depression and modest and transient response to ECT and who showed a robust and maintained response after six i.v. ketamine (0.5 mg/kg) infusions without withdrawing her antidepressant regimen. Ketamine was very well tolerated. This case illustrates the potential role of ketamine as a booster to standard antidepressants.