Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Psychiatry
Volume 2016, Article ID 6123913, 3 pages
http://dx.doi.org/10.1155/2016/6123913
Case Report

Loxapine and Cyproheptadine Combined Limit Clozapine Rebound Psychosis and May Also Predict Clozapine Response

1SUNY Downstate Medical Center, Department of Psychiatry, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
2Kingsboro Psychiatric Center, 681 Clarkson Avenue, Brooklyn, NY 11203, USA

Received 7 May 2016; Accepted 8 June 2016

Academic Editor: Toshiya Inada

Copyright © 2016 Lila Aboueid and Richard H. McCarthy. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Clozapine has been consistently shown to be superior to other antipsychotics in the treatment of psychosis. However, clozapine usage has been limited due to required routine blood monitoring and the potential for life threatening side effects. We report a case of a 66-year-old female patient, who developed clozapine-induced agranulocytosis after 10 weeks of clozapine treatment and was subsequently successfully treated with a combination of loxapine and cyproheptadine. The combination is thought to mimic the pharmacological profile of clozapine, rendering it as a possible alternative to traditional clozapine treatment.