Drug-Drug-Induced Akathisia: Two Case Reports

Table 1

Result of Naranjo Adverse Drug Reaction Probability Scale for Case A and Case B.

Question	Yes	No	Do not know	Case A score	Case B score
(1) Are there previous conclusive reports on this reaction?	+1	0	0	+1	+1
(2) Did the adverse event appear after the suspected drug was administered?	+2	-1	0	+2	+2
(3) Did the adverse reaction improve when the drug was discontinued or a specific antagonist was administered?	+1	0	0	+1^a	+1^a
(4) Did the adverse event reappear when the drug was readministered?	+2	-1	0	Not rechallenged	Not rechallenged
(5) Are there alternative causes (other than the drug) that could on their own have caused the reaction?	-1	+2	0	-1 (relapse)	0
(6) Did the reaction reappear when a placebo was given?	-1	+1	0	Not done	Not done^b
(7) Was the drug detected in the blood (or other fluids) in concentrations known to be toxic?	+1	0	0	Not done
(8) Was the reaction more severe when the dose was increased or less severe when the dose was decreased?	+1	0	0	0	0
(9) Did the patient have a similar reaction to the same or similar drugs in any previous exposure?	+1	0	0	0	0
(10) Was the adverse event confirmed by any objective evidence?	+1	0	0	+1	+1
Total score				+4	+5