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Case Reports in Pulmonology
Volume 2013, Article ID 794642, 3 pages
Case Report

Multifocal Extranodal Involvement of Diffuse Large B-Cell Lymphoma

1Department of Medical Oncology, Kocaeli University Hospital, Umuttepe, 41380 Kocaeli, Turkey
2Department of Pulmonary Disease, Kocaeli University Hospital, Umuttepe, 41380 Kocaeli, Turkey
3Department of Pathology, Kocaeli University Hospital, Umuttepe, 41380 Kocaeli, Turkey

Received 24 July 2013; Accepted 18 August 2013

Academic Editors: F. J. Aspa, L. Borderías, H. Matsuoka, and M. Takao

Copyright © 2013 Devrim Cabuk et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Endobronchial involvement of extrapulmonary malignant tumors is uncommon and mostly associated with breast, kidney, colon, and rectum carcinomas. A 68-year-old male with a prior diagnosis of colon non-Hodgkin lymphoma (NHL) was admitted to the hospital with a complaint of cough, sputum, and dyspnea. The chest radiograph showed right hilar enlargement and opacity at the right middle zone suggestive of a mass lesion. Computed tomography of thorax revealed a right-sided mass lesion extending to thoracic wall with the destruction of the third and the fourth ribs and a right hilar mass lesion. Fiberoptic bronchoscopy was performed in order to evaluate endobronchial involvement and showed stenosis with mucosal tumor infiltration in right upper lobe bronchus. The pathological examination of bronchoscopic biopsy specimen reported diffuse large B-cell lymphoma and the patient was accepted as the endobronchial recurrence of sigmoid colon NHL. The patient is still under treatment of R-ICE (rituximab-ifosfamide-carboplatin-etoposide) chemotherapy and partial regression of pulmonary lesions was noted after 3 courses of treatment.