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Case Reports in Pulmonology
Volume 2018, Article ID 9745935, 4 pages
https://doi.org/10.1155/2018/9745935
Case Report

Nodular Pulmonary Amyloidosis: A Manifestation of Sjögren’s Syndrome

1Specialist in Internal Medicine and Pneumology, Department of Internal Medicine, Universidad de Antioquia, San Vicente Foundation University Hospital, Colombia
2Specialist in Internal Medicine, Pneumology, Thoracic Oncology and Epidemiology, Department of Internal Medicine, Universidad de Antioquia, San Vicente Foundation University Hospital, Colombia
3Resident of Internal Medicine, Universidad del Cauca, Colombia
4Undergraduate Medical Student, Universidad de Antioquia, Colombia
5Resident of Internal Medicine, Universidad de Antioquia, Colombia
6Resident of Pathology, Universidad de Antioquia, Colombia
7Specialist in Pathology, Department of Pathology, Universidad de Antioquia, San Vicente Foundation University Hospital, Colombia

Correspondence should be addressed to Gustavo Adolfo Gómez Correa; moc.liamtoh@ocogsug

Received 29 January 2018; Revised 23 June 2018; Accepted 4 July 2018; Published 13 August 2018

Academic Editor: Akif Turna

Copyright © 2018 Gustavo Adolfo Gómez Correa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Case Description. A 72-year-old woman with primary Sjögren Syndrome (SS) was diagnosed during an inpatient hospital stay with dry symptoms. The patient had respiratory and constitutional symptoms, requiring a pulmonary imaging evaluation by high-resolution computed tomography (HRCT) of the thorax. Clinical Findings. Multiple cavitary pulmonary nodules, halo sign, and focal areas of ground-glass opacity with predominance in both bases were found in the images. Complementary studies were done where a neoplastic focus was ruled out. The diagnosis of nodular pulmonary amyloidosis was confirmed with a pulmonary biopsy performed by videothoracoscopy for histopathological study, which reported the formation of nodules in the parenchyma with amyloid deposits and positive immunohistochemical markers for CD3, CD20, and CD38 lymphocytic infiltration. Treatment and Outcome. Initial inpatient management with intravenous cyclophosphamide and methylprednisolone was given. Subsequent outpatient management was given with high dose glucocorticoids. Clinical Relevance. We presented a case of nodular pulmonary amyloidosis in a female patient with primary SS, which is a rare pulmonary manifestation of this syndrome.