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Case Reports in Radiology
Volume 2014, Article ID 617343, 5 pages
Case Report

Regional Cerebral Blood-Flow with 99mTc-ECD Brain Perfusion SPECT in Landau-Kleffner Syndrome: Report of Two Cases

1Department of Neurology, Bushehr Medical Center Hospital, Bushehr University of Medical Sciences, Bushehr 7533934698, Iran
2The Persian Gulf Tropical and Infectious Diseases Research Centre, Bushehr University of Medical Sciences, Bushehr 7533934698, Iran
3Golestan Research Center of Gastroenterology and Hepatology (GRCGH), Golestan University of Medical Sciences (GUOMS), Gorgan 4917765181, Iran
4The Persian Gulf Nuclear Medicine Research Center, Bushehr University of Medical Sciences, Bushehr 7533934698, Iran

Received 9 March 2014; Accepted 14 April 2014; Published 29 April 2014

Academic Editor: Alberto Spalice

Copyright © 2014 Reza Nemati et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Landau-Kleffner syndrome (LKS) is a rare childhood disorder characterized by acquired aphasia and epilepsy. 99mTc-ECD SPECT imaging was performed in two right-handed children with LKS. A relative decrease in perfusion was found in the left frontal-temporal cortices of both patients as well as in the left and right parietal cortices of one patient with aphasia, without clinical epilepsy. The degree of regional cerebral perfusion impairment did not correlate with the severity of the clinical and EEG abnormalities, but the area of hypoperfusion was compatible with the speech area of the brain. Overall, although asymmetrical temporoparietal perfusion appears as a common finding in LKS, SPECT findings in LKS alone cannot elucidate the pathogenic features of the disorder in the brain. Here, we present two cases of LKS in which we investigated SPECT perfusion scans.