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Case Reports in Radiology
Volume 2015, Article ID 536328, 4 pages
http://dx.doi.org/10.1155/2015/536328
Case Report

Adult Langerhans Cell Histiocytosis with Hepatic and Pulmonary Involvement

1Radiology Department, Centro Hospitalar de São João, Alameda Professor Hernâni Monteiro, 4200–319 Porto, Portugal
2Pathology Department, Centro Hospitalar de São João, Alameda Professor Hernâni Monteiro, 4200–319 Porto, Portugal

Received 16 February 2015; Accepted 9 April 2015

Academic Editor: Suayib Yalcin

Copyright © 2015 Bruno Araujo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Langerhans cell histiocytosis (LCH) is a rare proliferative disorder of Langerhans cells of unknown etiology. It can involve multiple organ systems with different clinical presentation, which complicates the diagnosis. It can range from isolated to multisystem disease with different prognosis. Although common among children, liver involvement is relatively rare in adults and frequently overlooked. Natural history of liver LCH fits into two stages: an early stage with infiltration by histiocytes and a late stage with sclerosis of the biliary tree. Pulmonary findings are more common and include multiple nodules in different stages of cavitation, predominantly in the upper lobes. We present a case of adult LCH with pulmonary and biopsy proven liver involvement with resolution of the hepatic findings after treatment.