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Case Reports in Radiology
Volume 2016, Article ID 9786925, 5 pages
Case Report

Giant Cell Tumor of Bone: Documented Progression over 4 Years from Its Origin at the Metaphysis to the Articular Surface

1Department of Radiology & Biomedical Imaging, University of California, San Francisco, 505 Parnassus Avenue, M-391, San Francisco, CA 94143-0628, USA
2Department of Orthopaedic Surgery, University of California, San Francisco, 1825 Fourth Street, Fourth Floor, San Francisco, CA 94158, USA
3Department of Pathology, University of California, San Francisco, 1825 Fourth Street, Room M2370, San Francisco, CA 94143, USA

Received 20 April 2016; Accepted 26 July 2016

Academic Editor: Toshihiro Akisue

Copyright © 2016 Colin Burke et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The exact location of origin for giant cell tumors of bone (GCTB) remains controversial, as lesions are not routinely imaged early but rather late when the tumor is large and clinically symptomatic. At the time of diagnosis, GCTB are classically described as lucent, eccentric lesions with nonsclerotic margins, located within the epiphysis to a greater extent than the metaphysis. Here we present a case of a biopsy proven GCTB initially incidentally seen on MRI as a small strictly metaphyseal lesion, which over the course of several years expanded across a closed physis to involve the epiphysis and abut the articular surface/subchondral bone plate.