Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Rheumatology
Volume 2011, Article ID 242681, 6 pages
http://dx.doi.org/10.1155/2011/242681
Case Report

Association of Sweet's Syndrome and Systemic Lupus Erythematosus

Division of Rheumatology, Department of Medicine, University of California, San Francisco, CA 94143, USA

Received 9 August 2011; Accepted 29 August 2011

Academic Editors: A. Chalmers and J. C. Nossent

Copyright © 2011 J. L. Barton et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Sweet's syndrome is an acute febrile neutrophilic dermatosis which usually presents as an idiopathic disorder but can also be drug induced, associated with hematopoetic malignancies and myelodysplastic disorders, and more, infrequently, observed in autoimmune disorders. Sweet's syndrome has been reported in three cases of neonatal lupus, three cases of hydralazine-induced lupus in adults, and in nine pediatric and adult systemic lupus erythematosus (SLE) patients. We describe three additional adult cases of Sweet's associated with SLE and provide a focused review on nondrug-induced, nonneonatal SLE and Sweet's. In two of three new cases, as in the majority of prior cases, the skin rash of Sweet's paralleled underlying SLE disease activity. The pathogenesis of Sweet's remains elusive, but evidence suggests that cytokine dysregulation may be central to the clinical and pathological changes in this condition, as well as in SLE. Further research is needed to define the exact relationship between the two conditions.