Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Rheumatology
Volume 2011, Article ID 951948, 4 pages
http://dx.doi.org/10.1155/2011/951948
Case Report

Generalized Morphea after Breast Cancer Radiation Therapy

Department of Rheumatology, Medical College of Wisconsin, FEC 4764, 9200 W. Wisconsin Avenue, Milwaukee, WI 53226, USA

Received 24 August 2011; Accepted 15 September 2011

Academic Editor: C. Schubert

Copyright © 2011 Jonathan Kushi and M. E. Csuka. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. N. Fett and V. P. Werth, “Update on morphea: part I. Epidemiology, clinical presentation, and pathogenesis,” Journal of the American Academy of Dermatology, vol. 64, no. 2, pp. 217–228, 2011. View at Publisher · View at Google Scholar · View at PubMed
  2. R. M. Laxer and F. Zulian, “Localized scleroderma,” Current Opinion in Rheumatology, vol. 18, no. 6, pp. 606–613, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  3. J. V. Schaffer, C. Carroll, I. Dvoretsky, M. J. Huether, and M. Girardi, “Postirradiation morphea of the breast: presentation of two cases and review of the literature,” Dermatology, vol. 200, no. 1, pp. 67–71, 2000. View at Google Scholar · View at Scopus
  4. S. M. Reddy, J. C. Pui, L. I. Gold, and H. J. Mitnick, “Postirradiation morphea and subcutaneous polyarteritis nodosa: case report and literature review,” Seminars in Arthritis and Rheumatism, vol. 34, no. 5, pp. 728–734, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  5. T. Herrmann, C. Günther, and P. Csere, “Localized Morphea—a rare but significant secondary complication following breast cancer radiotherapy : case report and review of the literature on radiation reaction among patients with scleroderma/morphea,” Strahlentherapie und Onkologie, vol. 185, no. 9, pp. 603–607, 2009. View at Publisher · View at Google Scholar · View at PubMed
  6. L. S. Peterson, A. M. Nelson, W. P. D. Su, T. Mason, W. M. O'Fallon, and S. E. Gabriel, “The epidemiology of morphea (localized scleroderma) in Olmsted County 1960–1993,” Journal of Rheumatology, vol. 24, no. 1, pp. 73–80, 1997. View at Google Scholar · View at Scopus
  7. K. J. Murray and R. M. Laxer, “Scleroderma in children and adolescents,” Rheumatic Disease Clinics of North America, vol. 28, no. 3, pp. 603–624, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. D. A. Davis, P. R. Cohen, M. D. McNeese, and M. Duvic, “Localized scleroderma in breast cancer patients treated with supervoltage external beam radiation: radiation port scleroderma,” Journal of the American Academy of Dermatology, vol. 35, no. 6, pp. 923–927, 1996. View at Publisher · View at Google Scholar · View at Scopus
  9. N. R. Bleasel, K. M. Stapleton, C. Commens, and V. A. Ahern, “Radiation-induced localized scleroderma in breast cancer patients,” Australasian Journal of Dermatology, vol. 40, no. 2, pp. 99–102, 1999. View at Publisher · View at Google Scholar · View at Scopus
  10. G. B. Colver, A. Rodger, P. S. Mortimer, J. A. Savin, S. M. Neill, and J. A. A. Hunter, “Post-irradiation morphoea,” British Journal of Dermatology, vol. 120, no. 6, pp. 831–835, 1989. View at Google Scholar · View at Scopus
  11. K. J. Smith, J. Yeager, H. G. Skelton, P. R. Cohen, D. A. Davis, and M. Duvic, “Localized scleroderma in breast cancer patients treated with supervoltage external beam radiation: radiation port scleroderma,” Journal of the American Academy of Dermatology, vol. 37, part 1, no. 5, pp. 806–808, 1997. View at Google Scholar · View at Scopus
  12. S. G. Cooper and J. W. Denham, “Progressive systemic sclerosis (diffuse scleroderma) and radiotherapy,” British Journal of Radiology, vol. 63, no. 754, pp. 804–805, 1990. View at Google Scholar · View at Scopus
  13. M. Abu-Shakra, F. Guillemin, and P. Lee, “Cancer in systemic sclerosis,” Arthritis and Rheumatism, vol. 36, no. 4, pp. 460–464, 1993. View at Google Scholar · View at Scopus
  14. B. Kreft, J. Wohlrab, K. Radant, B. Danz, W. C. Marsch, and E. Fiedler, “Unrecognized radiation-induced localized scleroderma: a cause of postoperative wound-healing disorder,” Clinical and Experimental Dermatology, vol. 34, no. 7, pp. e383–e384, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  15. H. Ullén and E. Björkholm, “Localized scleroderma in a woman irradiated at two sites for endometrial and breast carcinoma: a case history and a review of the literature,” International Journal of Gynecological Cancer, vol. 13, no. 1, pp. 77–82, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. B. N. Akay, H. Sanli, and A. O. Heper, “Postirradiation linear morphoea,” Clinical and Experimental Dermatology, vol. 35, no. 4, pp. e106–e108, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  17. J. L. Harper, L. E. Franklin, J. M. Jenrette, and E. G. Aguero, “Skin toxicity during breast irradiation: pathophysiology and management,” Southern Medical Journal, vol. 97, no. 10, pp. 989–993, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. J. O. Archambeau, R. Pezner, and T. Wasserman, “Pathophysiology of irradiated skin and breast,” International Journal of Radiation Oncology Biology Physics, vol. 31, no. 5, pp. 1171–1185, 1995. View at Publisher · View at Google Scholar
  19. F. Meric, T. A. Buchholz, N. Q. Mirza et al., “Long-term complications associated with breast-conservation surgery and radiotherapy,” Annals of Surgical Oncology, vol. 9, no. 6, pp. 543–549, 2002. View at Publisher · View at Google Scholar · View at Scopus
  20. H. R. Crocker, Diseases of the Skin Their Description, Pathology, Diagnosis and Treatment, P. Blakiston's Son & Co., Philadelphia, Pa, USA, 1905.
  21. P. A. Morganroth, D. Dehoratius, H. Curry, and R. Elenitsas, “Postirradiation morphea: a case report with a review of the literature and summary of the clinicopathologic differential diagnosis,” The American Journal of Dermatopathology. In press.
  22. J. Wo and A. Taghian, “Radiotherapy in setting of collagen vascular disease,” International Journal of Radiation Oncology Biology Physics, vol. 69, no. 5, pp. 1347–1353, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  23. A. V. Marzano, S. Menni, A. Parodi et al., “Localized scleroderma in adults and children. Clinical and laboratory investigations of 239 cases,” European Journal of Dermatology, vol. 13, no. 2, pp. 171–176, 2003. View at Google Scholar · View at Scopus
  24. J. Varga, U. F. Haustein, R. H. Creech, J. P. Dwyer, and S. A. Jimenez, “Exaggerated radiation-induced fibrosis in patients with systemic sclerosis,” Journal of the American Medical Association, vol. 265, no. 24, pp. 3292–3295, 1991. View at Publisher · View at Google Scholar · View at Scopus
  25. H. Higley, K. Persichitte, S. Chu, W. Waegell, R. Vancheeswaran, and C. Black, “Immunocytochemical localization and serologic detection of transforming growth factor β1: association with type I procollagen and inflammatory cell markers in diffuse and limited systemic sclerosis, morphea, and Raynaud's phenomenon,” Arthritis and Rheumatism, vol. 37, no. 2, pp. 278–288, 1994. View at Google Scholar · View at Scopus
  26. M. Kubo, H. Ihn, K. Yamane, and K. Tamaki, “Up-regulated expression of transforming growth factor β receptors in dermal fibroblasts in skin sections from patients with localized scleroderma,” Arthritis and Rheumatism, vol. 44, no. 3, pp. 731–734, 2001. View at Publisher · View at Google Scholar · View at Scopus
  27. M. K. Ozbilgin and S. Inan, “The roles of transforming growth factor type β3(TGF-β3) and mast cells in the pathogenesis of scleroderma,” Clinical Rheumatology, vol. 22, no. 3, pp. 189–195, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  28. M. R. Ardern-Jones and M. M. Black, “Widespread morphoea following radiotherapy for carcinoma of the breast,” Clinical and Experimental Dermatology, vol. 28, no. 2, pp. 160–162, 2003. View at Publisher · View at Google Scholar · View at Scopus
  29. N. L. C. Cheah, D. W. Y. Wong, and A. D. Chetiyawardana, “Radiation-induced morphea of the breast: a case report,” Journal of Medical Case Reports, vol. 2, article 136, 2008. View at Publisher · View at Google Scholar · View at PubMed