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Case Reports in Rheumatology
Volume 2012, Article ID 517059, 4 pages
Case Report

The Coexistence of Systemic Lupus Erythematosus and Thyrotoxicosis: The Diagnostic Value of Antihistone Antibodies

1Department of Clinical Immunology, University Hospital Alexandrovska, Sofia, Bulgaria
2Department of Dermatology and Venereology, Medical University, 9002 Varna, Bulgaria
3Department of Internal Medicine II, University Hospital Alexandrovska, Sofia, Bulgaria
4Department of Dermatology and Venereology, University Hospital Alexandrovska, Sofia, Bulgaria
5Department of Nephrology, University Hospital Alexandrovska, Sofia, Bulgaria

Received 5 January 2012; Accepted 19 February 2012

Academic Editors: D. Aeberli, A. Giusti, and J. Mikdashi

Copyright © 2012 Marta Baleva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We report four female patients with Graves' disease with positive ANA antibodies and possibility for development of systemic lupus erythematosus. All four patients have been treated with antithyroid drugs. SLE symptoms have appeared from 4 to 12 months after the beginning of therapy with methysol in two of them. The third patient had no symptoms for SLE, but her ANA, anti-DNA, and antihistone antibodies had been positive at the time of the onset of thyrotoxicosis. The fourth patient had alopecia areata with positive ANA and antihistone antibodies.