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Case Reports in Rheumatology
Volume 2012, Article ID 923897, 3 pages
Case Report

Efficacy and Safety of Rituximab in the Treatment of Vasculitic Leg Ulcers Associated with Hepatitis C Virus Infection

1Rheumatology Unit, Fundación Valle del Lili, ICESI University, Cali, Colombia
2Internal Medicine Department, Fundación Valle del Lili, ICES University, Cali, Colombia
3Fundación Valle del Lili and Medical School, University of Valle, Cali, Colombia

Received 31 October 2012; Accepted 29 November 2012

Academic Editors: C. Orellana and H. Tennen

Copyright © 2012 Fabio Bonilla-Abadía et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Vasculitic leg ulcers are a cutaneous manifestation of hepatitis C virus (HCV) infection often associated with cryoglobulinemia. Their treatment is difficult and is based on steroids and immunosuppressive drugs with an erratic response and a high probability of adverse reaction. We report three patients with vasculitic leg ulcers associated with hepatitis C virus infection who were treated successfully with rituximab. The pain control and healing were achieved quickly. No adverse effects with rituximab in these patients were presented.