Severe Eosinophilic Syndrome Associated with the Use of Probiotic Supplements: A New Entity?
Case 1 (A and B). (a) Cryostat section of quadriceps muscle stained with hematoxylin and eosin demonstrates a severe necrotizing vasculitis of an intramuscular arteriole. Intramural fibrinoid necrosis is evident (arrow). Surrounding the vessel are large numbers of macrophages, lymphocytes, and eosinophils (original magnification 100x). (b) High-magnification image of formalin fixed, paraffin-embedded tissue with an intramuscular vessel demonstrating large numbers of intramural and perivascular eosinophils (original magnification 400x).