Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Rheumatology
Volume 2013, Article ID 769127, 2 pages
Case Report

Severe Eosinophilic Syndrome: Highly Unlikely Associated with the Use of Probiotic Supplements!

1Active Nutrition, DuPont Nutrition and Health, 02460 Kantvik, Finland
2Department of Science, University College Roosevelt, 4330 AB Middelburg, The Netherlands

Received 4 February 2013; Accepted 18 February 2013

Academic Editors: K. P. Makaritsis and P. E. Prete

Copyright © 2013 Arthur C. Ouwehand and Ger T. Rijkers. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A recent report in this journal suggested a causal relation between probiotic consumption and eosinophilia. In our opinion, the data presented does not suggest such a relationship. The two described eosinophilia cases have not been shown to be caused by infection and certainly not by probiotic infection. The consumed probiotics could not be retrieved in shops, so their identity remains unknown. Furthermore, the alleged consumption took place 2–4 weeks prior to the onset of the symptoms; during such time period, probiotics tend to have disappeared from the intestine. Because most probiotic health benefits are strain specific, also potential risks are strain specific. Thus, generalizing a risk to probiotics as a class is incorrect. We do, however, agree with the authors of the case report that quality control of probiotics should be rigorous. We also do not dispute that there may be certain risk groups (e.g. severely immune-compromised patients), where probiotic use should be carefully monitored. In conclusion, the data presented in the case report do not indicate that specific probiotics strains might cause eosinophilia.