A Case of Rheumatoid Arthritis and Limited Systemic Sclerosis Overlap Successfully Treated with Tocilizumab for Arthritis and Concomitant Generalized Lymphadenopathy and Primary Biliary Cirrhosis
Histopathological and histoimmunochemical features of lymph node biopsy. Lymph node biopsy showed follicular hyperplasia and germinal center proliferation with narrowed mantle-zone ((a): HE stain, ×20). No dysplasia was seen in germinal center and hemophagocytic cells are scattered in this area ((b): HE stain, ×100). The lymphocytes forming in the germinal center were CD20 positive (c), BCL-2 negative (d), and IL-6 positive (e). Plasmacytes in interfollicular area were also IL-6 positive (f).