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Case Reports in Rheumatology
Volume 2014, Article ID 763608, 4 pages
http://dx.doi.org/10.1155/2014/763608
Case Report

Response to Rituximab in a Case of Lupus Associated Digital Ischemia

1Department of Rheumatology, Ankara University Medical Faculty, Sihhiye, 06410 Ankara, Turkey
2Department of Internal Medicine, Ankara University Medical Faculty, Sihhiye, 06410 Ankara, Turkey

Received 22 May 2014; Revised 27 June 2014; Accepted 29 June 2014; Published 9 July 2014

Academic Editor: Jamal Mikdashi

Copyright © 2014 Orhan Küçükşahin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We report the case of a 38-year-old female patient with systemic lupus erythematosus (SLE) and Jaccoud arthritis (JA) that sequentially developed digital ischemic lesions of the hands. In spite of follow-up treatment with glucocorticoids, immunosuppressant, antiaggregant, and potent vasodilatator agents, a serious progression to digital gangrene over a one-month period was observed. Surprisingly, her nonhealing digital lesions improved after two cycles of rituximab (RTX) administration.