Sarcoidosis and Histoplasmosis: Is One a Consequence of the Other? A Case Report and Review of the Literature

Table 1

Shared characteristics and differences between histoplasmosis and sarcoidosis.

	Histoplasmosis	Sarcoidosis
Clinical symptoms	Cough	Cough
	Dyspnea	Dyspnea
	Adrenal involvement	Adrenal involvement
	Erythema nodosum	Erythema nodosum
	Splenomegaly	Splenomegaly
	Anorexia	Anorexia
	Fever	Fever
	Arthralgia	Arthralgia
	Skin ulcers	Skin ulcers
	Uveitis/retinitis	Uveitis/retinitis
	Hepatitis	Hepatitis
	Parotid gland involvement	Parotid gland involvement
	Cervical myelopathy	Cervical myelopathy
Laboratory findings	Histology	Histology: noncaseating granulomas
	Cultures (bronchoalveolar lavage)	Elevated angiotensin converting enzyme
	Immunoassays	Elevated vitamin D
		Gammaglobulinemia
		Kveim
Radiographic findings	Hilar lymphadenopathy	Hilar lymphadenopathy
	Fibrosing mediastinitis	Upper lobe involvement
	Nodules	Nodules
	Reticulonodular opacities	Reticulonodular opacities
		Granulomas along lymphatic vessels
		Air trapping
Treatment	Itraconazole/amphotericin	Prednisone
	Streptomycin
	Bacillomycin B