Successful Treatment with Intravenous Cyclophosphamide for Refractory Adult-Onset Still’s Disease

Table 1

Laboratory findings on admission.

Peripheral blood
Red blood cells	382 × 10^6/μL
Hemoglobin	12.0 g/dL
Hematocrit	33.9%
White blood cells	26,000/μL
Neutrophil	90.0%
Monocyte	3.0%
Lymphocyte	5.0%
Platelet	29.3 × 10^4/μL
Blood chemistry
Total protein	5.7 g/dL
Total bilirubin	1.0 mg/dL
AST	34 IU/L (7−33)
ALT	22 IU/L (5−30)
Lactate dehydrogenase	1095 IU/L (119−229)
Alkaline phosphatase	611 IU/L (80−250)
Gamma-glutamyl transpeptidase	257 IU/L (5−55)
Creatinine kinase	14 IU/L (60−160)
Total cholesterol	186 mg/dL
Triglyceride	225 mg/dL
Blood urea nitrogen	13.6 mg/dL
Creatinine	0.4 mg/dL
Alb	2.1 g/dL
Na	131 mEq/L
K	4.1 mEq/L
Cl	91 mEq/L
Serological tests
C-reactive protein	9.95 mg/dL (<30)
Erythrocyte sedimentation rate	71.0 mm/hr
Ferritin	11740 ng/mL (<170)
C3	142 mg/dL (86–160)
C4	26 mg/dL (17–45)
ANA	(—) (<40)
Anti-CCP Ab	<0.6 U/mL (<4.5)
MPO-ANCA	<1.0 U/mL
RR3-ANCA	<1.0 U/mL
IgG	1340 mg/dL (900–2000)
IgM	108 mg/dL
IgA	338 mg/dL
sIL-2R	1850 U/mL
Coagulation
PT time (INR)	67.8% (1.19)
fibrinogen	684.2 mg/dL
FDP	13.2 μg/mL
Microbiological test
HCV-Ab	(—)
HBsAg	(—)
CMV antigenemia	(—)
EBV-EBNA	×40
EBV-VCA IgM	<×10
EBV-VCA IgG	×160
Blood culture	(—)
β-D-Glucan	<3.4 pg/mL
Urinalysis	Normal

ANA: anti-nuclear antibody; ANCA: antineutrophil cytoplasmic antibody; CMV: cytomegalovirus; EBV EBNA: Epstein-Barr virus, nuclear antigen; EBV-VCA: Epstein-Barr virus viral-capsid antigen; HBsAg: hepatitis B surface antigen; HCV: hepatitis C virus; MMP-3: matrix metalloproteinase-3; MPO: myeloperoxidase; RF: rheumatoid factor; RR3: proteinase 3.