Fatal Cytomegalovirus Disease after Combination Therapy with Corticosteroids and Rituximab for Granulomatosis with Polyangiitis

Table 1

Time course of illness with corresponding PR3 level, treatment regimen, and reactivation of CMV disease.

	Day 5	Day 10	Day 20	Day 25	Day 30	Day 40
PR3 level	1351	767	383		310	150
Corticosteroid	Prednisone; 80 mg	Prednisone; 80 mg	Prednisone; 80 mg	Prednisone; 70 mg	Prednisone; 70 mg	Prednisone; 70 mg
Rituximab		Second dose	Third dose		Fourth dose
Symptoms and signs of CMV disease				Hypoxia, fever	Worsening pulmonary infiltrates	Persistent viremia