Case Reports in Rheumatology / 2015 / Article / Tab 1

Case Report

Glucocorticoid-Responsive Cold Agglutinin Disease in a Patient with Rheumatoid Arthritis

Table 1

Characteristics of the patients who had CAD associated with connective tissue diseases.

Case numberDiagnosisAge, sexRaynaud’s phenomenon or acrocyanosisSplenomegalyCA titer Monoclonal IgMHb (g/dL)Treatment

1SSc60, FYesYes1 : 256No6.1 Pulse + mPSL (60 mg)

2SS78, FYesn.d.1 : 64n.d.5.0 PSL (10 mg), dopamine, pyridoxal, PGE1, and systemic warming

3SLE55, Fn.d.n.d.1 : 512n.d.7.9 Pulse with PSL (30 mg) relapse: PSL (40 mg), DFPP, CyA, and RTX

4SLE27, FNoNo1 : 7000No6.7 Prednisone (40 mg) and plaquenil

5SLE34, FNoYes1 : 4096n.d.6.0PSL (60 mg)

6RA52, Fn.d.n.d.1 : 512No9.1 PSL (1 mg/kg), CyA, and RTX

7RA89, FYesNo1 : 320No31%Hydroxychloroquine

8PMR60, MYesn.d.1 : 256Yes8.0 Avoiding cold

Present caseRA57, MNoNo1 : 2048No6.2 PSL (1 mg/kg)

CA, cold agglutinin; CAD, cold agglutinin disease; CyA, cyclosporin; DFPP, double-filtration plasmapheresis; Hb, hemoglobin; Ht, hematocrit; mPSL, methylprednisolone; n.d., not described; PGE1, prostaglandin E1; PMR, polymyalgia rheumatica; PSL, prednisolone; RA, rheumatoid arthritis; RTX, rituximab; SLE, systemic lupus erythematosus; SS, Sjögren’s syndrome; SSc, systemic sclerosis. The titer was measured at room temperature. Hematocrit.

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.