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Case Reports in Rheumatology
Volume 2016, Article ID 1718309, 4 pages
Case Report

Swift and Complete Healing of Digital Ulcers after Macitentan Treatment

Servicio de Reumatología, Hospital Obispo Polanco, Teruel, Spain

Received 11 October 2016; Accepted 1 November 2016

Academic Editor: James V. Dunne

Copyright © 2016 Emilio Giner Serret. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Digital ulcers are a burdensome and painful condition with sparse options of treatment. We report the case of a 78-year-old female patient with limited cutaneous systemic sclerosis that sequentially developed digital ulcers. After the appearance of digital ulcers in the soles of her feet she was successfully treated with bosentan. The report of two new digital ulcers in her hands 9 months later alongside with elevated transaminase levels led to a switch to macitentan treatment. A swift and complete healing of both digital ulcers was observed after 3 months, with the restoration of normal biochemical values.