Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Rheumatology
Volume 2016 (2016), Article ID 1718309, 4 pages
http://dx.doi.org/10.1155/2016/1718309
Case Report

Swift and Complete Healing of Digital Ulcers after Macitentan Treatment

Servicio de Reumatología, Hospital Obispo Polanco, Teruel, Spain

Received 11 October 2016; Accepted 1 November 2016

Academic Editor: James V. Dunne

Copyright © 2016 Emilio Giner Serret. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. C. LeRoy, C. Black, R. Fleischmajer et al., “Scleroderma (systemic sclerosis): classification, subsets and pathogenesis,” Journal of Rheumatology, vol. 15, no. 2, pp. 202–205, 1988. View at Google Scholar · View at Scopus
  2. F. K. Tan, “Systemic sclerosis: the susceptible host (genetics and environment),” Rheumatic Disease Clinics of North America, vol. 29, no. 2, pp. 211–237, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. M. C. Arias-Nuñez, J. Llorca, T. R. Vazquez-Rodriguez et al., “Systemic sclerosis in northwestern Spain: a 19-year epidemiologic study,” Medicine, vol. 87, no. 5, pp. 272–280, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. C. P. Simeón-Aznar, V. Fonollosa-Plá, C. Tolosa-Vilella et al., “Registry of the Spanish Network for Systemic Sclerosis: clinical pattern according to cutaneous subsets and immunological status,” Seminars in Arthritis and Rheumatism, vol. 41, no. 6, pp. 789–800, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. C. Mihai, R. Landewé, D. van der Heijde et al., “Digital ulcers predict a worse disease course in patients with systemic sclerosis,” Annals of the Rheumatic Diseases, vol. 75, no. 4, pp. 681–686, 2016. View at Publisher · View at Google Scholar
  6. L. Mouthon, C. Mestre-Stanislas, A. Bérezné et al., “Impact of digital ulcers on disability and health-related quality of life in systemic sclerosis,” Annals of the Rheumatic Diseases, vol. 69, no. 1, pp. 214–217, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Brand, R. Hollaender, D. Rosenberg et al., “An observational cohort study of patients with newly diagnosed digital ulcer disease secondary to systemic sclerosis registered in the EUSTAR database,” Clinical and Experimental Rheumatology, vol. 33, pp. S47–S54, 2015. View at Google Scholar · View at Scopus
  8. D. Khanna, C. P. Denton, P. A. Merkel et al., “Effect of macitentan on the development of new ischemic digital ulcers in patients with systemic sclerosis: DUAL-1 and DUAL-2 randomized clinical trials,” Journal of the American Medical Association, vol. 315, no. 18, pp. 1975–1988, 2016. View at Publisher · View at Google Scholar
  9. P. N. Sidharta, P. L. M. van Giersbergen, and J. Dingemanse, “Safety, tolerability, pharmacokinetics, and pharmacodynamics of macitentan, an endothelin receptor antagonist, in an ascending multiple-dose study in healthy subjects,” Journal of Clinical Pharmacology, vol. 53, no. 11, pp. 1131–1138, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. J. Gatfield, C. M. Grandjean, T. Sasse, M. Clozel, and O. Nayler, “Slow receptor dissociation kinetics differentiate macitentan from other endothelin receptor antagonists in pulmonary arterial smooth muscle cells,” PLoS ONE, vol. 7, no. 10, Article ID e47662, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. J. H. Korn, M. Mayes, M. Matucci Cerinic et al., “Digital ulcers in systemic sclerosis: prevention by treatment with bosentan, an oral endothelin receptor antagonist,” Arthritis and Rheumatism, vol. 50, no. 12, pp. 3985–3993, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Matucci-Cerinic, C. P. Denton, D. E. Furst et al., “Bosentan treatment of digital ulcers related to systemic sclerosis: Results from the RAPIDS-2 randomised, double-blind, placebo-controlled trial,” Annals of the Rheumatic Diseases, vol. 70, no. 1, pp. 32–38, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Chamaillard, I. Heliot-Hosten, J. Constans, and A. Taïeb, “Bosentan as a rescue therapy in scleroderma refractory digital ulcers,” Archives of Dermatology, vol. 143, no. 1, pp. 125–126, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. M. J. Snyder, M. R. Jacobs, R. G. Grau, D. S. Wilkes, and K. S. Knox, “Resolution of severe digital ulceration during a course of bosentan therapy,” Annals of Internal Medicine, vol. 142, no. 9, pp. 802–803, 2005. View at Google Scholar · View at Scopus
  15. J. A. Roman Ivorra, C. P. Simeon, J. J. Alegre Sancho et al., “Bosentan in clinical practice for treating digital and other ischemic ulcers in Spanish patients with systemic sclerosis: IBER-DU cohort study,” The Journal of Rheumatology, vol. 38, no. 8, pp. 1631–1635, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. D. Launay, É. Diot, É. Pasquier et al., “Bosentan for treatment of active digital ulcers in patients with systemic sclerosis,” La Presse Médicale, vol. 35, no. 4, part 1, pp. 587–592, 2006. View at Publisher · View at Google Scholar
  17. Y. Nagai, M. Hasegawa, T. Hattori, E. Okada, O. Tago, and O. Ishikawa, “Bosentan for digital ulcers in patients with systemic sclerosis,” Journal of Dermatology, vol. 39, no. 1, pp. 48–51, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. N. Tsifetaki, V. Botzoris, Y. Alamanos, E. Argyriou, A. Zioga, and A. A. Drosos, “Bosentan for digital ulcers in patients with systemic sclerosis: a prospective 3-year followup study,” Journal of Rheumatology, vol. 36, no. 7, pp. 1550–1551, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. Z. Kurgyis, R. Varga, I. Sick, M. U. Lang, T. Ruzicka, and M. Sárdy, “Bosentan is effective against digital ulcerations and hyperkeratosis in systemic sclerosis,” Acta Dermato-Venereologica, vol. 91, no. 6, pp. 716–717, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. F. M. Wigley, J. R. Seibold, R. A. Wise, D. A. McCloskey, and W. P. Dole, “Intravenous iloprost treatment of Raynaud's phenomenon and ischemic ulcers secondary to systemic slcerosis,” Journal of Rheumatology, vol. 19, no. 9, pp. 1407–1414, 1992. View at Google Scholar · View at Scopus
  21. D. B. Badesch, V. F. Tapson, M. D. McGoon et al., “Continuous intravenous epoprostenol for pulmonary hypertension due to the scleroderma spectrum of disease. A randomized, controlled trial,” Annals of Internal Medicine, vol. 132, no. 6, pp. 425–434, 2000. View at Google Scholar · View at Scopus
  22. R. Scorza, M. Caronni, B. Mascagni et al., “Effects of long-term cyclic iloprost therapy in systemic sclerosis with Raynaud's phenomenon. A randomized, controlled study,” Clinical and Experimental Rheumatology, vol. 19, no. 5, pp. 503–508, 2001. View at Google Scholar · View at Scopus
  23. A. Abou-Raya, S. Abou-Raya, and M. Helmii, “Statins: potentially useful in therapy of systemic sclerosis-related Raynaud's phenomenon and digital ulcers,” Journal of Rheumatology, vol. 35, no. 9, pp. 1801–1808, 2008. View at Google Scholar · View at Scopus