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Case Reports in Rheumatology
Volume 2016, Article ID 8352893, 4 pages
Case Report

Rituximab Not Effective for Hearing Loss in Cogan’s Syndrome

Department of Medicine, Division of Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA

Received 14 June 2016; Accepted 7 September 2016

Academic Editor: Gregory J. Tsay

Copyright © 2016 Daniel R. Bunker and Leslie Dubin Kerr. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Importance. Rituximab was not effective in ameliorating the hearing loss in a patient with atypical Cogan’s syndrome. Observations. We report the case of a patient who developed acute bilateral uveitis and sensorineural hearing loss. A diagnosis of atypical Cogan’s syndrome was made. The patient’s hearing loss did not improve despite high dose steroids and azathioprine. Rituximab was administered given a recent report of its efficacy in a patient with refractory disease; however, our patient’s hearing loss did not improve. Conclusion. Hearing loss in Cogan’s syndrome is difficult to treat. Though rituximab was ineffective in our case, earlier administration in the disease course could be effective for future patients.