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Case Reports in Rheumatology
Volume 2017, Article ID 6031053, 7 pages
https://doi.org/10.1155/2017/6031053
Case Report

Efficacy of Rituximab in a Systemic Lupus Erythematosus Patient Presenting with Diffuse Alveolar Hemorrhage

Division of Rheumatology, Department of Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, PR, USA

Correspondence should be addressed to Luis M. Vilá; ude.rpu@2aliv.siul

Received 26 July 2017; Revised 17 October 2017; Accepted 22 October 2017; Published 15 November 2017

Academic Editor: Jamal Mikdashi

Copyright © 2017 Gabriela Montes-Rivera et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. R. Zamora, M. L. Warner, R. Tuder, and M. I. Schwarz, “Diffuse alveolar hemorrhage and systemic lupus erythematosus. Clinical presentation, histology, survival, and outcome,” Medicine, vol. 76, no. 3, pp. 192–202, 1997. View at Publisher · View at Google Scholar · View at Scopus
  2. A. S. Santos-Ocampo, B. F. Mandell, and B. J. Fessler, “Alveolar hemorrhage in systemic lupus erythematosus: presentation and management,” Chest, vol. 118, no. 4, pp. 1083–1090, 2000. View at Publisher · View at Google Scholar
  3. Y. Santiago-Casas and L. M. Vilá, “Pulmonary hemorrhage in patients with systemic lupus erythematosus,” Current Respiratory Medicine Reviews, vol. 5, no. 1, pp. 49–54, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. J. Z. Gillis, M. Dall’era, A. Gross, J. Yazdany, and J. Davis, “Six refractory lupus patients treated with rituximab: a case series,” Arthritis & Rheumatism, vol. 57, no. 3, pp. 538–542, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. C. M. Nellessen, U. Pöge, K. A. Brensing, T. Sauerbruch, H. U. Klehr, and C. Rabe, “Diffuse alveolar haemorrhage in a systemic lupus erythematosus patient successfully treated with rituximab: a case report,” Nephrology Dialysis Transplantation, vol. 23, no. 1, pp. 385-386, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. L. F. Pinto, L. Candia, P. Garcia et al., “Effective treatment of refractory pulmonary hemorrhage with monoclonal anti-CD20 antibody (rituximab),” Respiration, vol. 78, no. 1, pp. 106–109, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. C. B. Narshi, S. Haider, C. M. Ford, D. A. Isenberg, and I. P. Giles, “Rituximab as early therapy for pulmonary haemorrhage in systemic lupus erythematosus,” Rheumatology, vol. 49, no. 2, pp. 392–394, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. D. J. Todd and K. H. Costenbader, “Dyspnoea in a young woman with active systemic lupus erythematosus,” Lupus, vol. 18, no. 9, pp. 777–784, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. V. Pottier, M. Pierrot, J. F. Subra et al., “Successful rituximab therapy in a lupus patient with diffuse alveolar haemorrhage,” Lupus, vol. 20, no. 6, pp. 656–659, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. M. U. Martínez-Martínez and C. Abud-Mendoza, “Recurrent diffuse alveolar haemorrhage in a patient with systemic lupus erythematosus: long-term benefit of rituximab,” Lupus, vol. 21, no. 10, pp. 1124–1127, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. C. Gonzalez-Echavarri, B. Pernas, A. Ugarte, and G. Ruiz-Irastorza, “Severe multiorganic flare of systemic lupus erythematosus successfully treated with rituximab and cyclophosphamide avoiding high doses of prednisone,” Lupus, vol. 23, no. 3, pp. 323–326, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. R. C. Esper, I. E. Estrada, T. de la Torre León, A. O. Gutiérrez, and J. A. López, “Treatment of diffuse alveolar hemorrhage secondary to lupus erythematosus with recombinant activated factor VII administered with a jet nebulizer,” Journal of Intensive Care, vol. 2, no. 1, p. 47, 2014. View at Publisher · View at Google Scholar · View at Scopus
  13. J. R. Tse, K. E. Schwab, M. McMahon, and W. Simon, “Rituximab: an emerging treatment for recurrent diffuse alveolar hemorrhage in systemic lupus erythematosus,” Lupus, vol. 24, no. 7, pp. 756–759, 2015. View at Publisher · View at Google Scholar · View at Scopus
  14. J. O. Na, S. H. Chang, K.-H. Seo et al., “Successful early rituximab treatment in a case of systemic lupus erythematosus with potentially fatal diffuse alveolar hemorrhage,” Respiration, vol. 89, no. 1, pp. 62–65, 2015. View at Publisher · View at Google Scholar · View at Scopus
  15. S. Aakjær, E. Bendstrup, P. Ivarsen, and L. B. Madsen, “Continous rituximab treatment for recurrent diffuse alveolar hemorrhage in a patient with systemic lupus erythematosus and antiphosholipid syndrome,” Respiratory Medicine Case Reports, vol. 22, pp. 263–265, 2017. View at Publisher · View at Google Scholar
  16. F. Verzegnassi, F. Marchetti, F. Zennaro, A. Saccari, A. Ventura, and L. Lepore, “Prompt efficacy of plasmapheresis in a patient with systemic lupus erythematosus and diffuse alveolar haemorrhage,” Clinical and Experimental Rheumatology, vol. 28, no. 3, pp. 445-446, 2010. View at Google Scholar
  17. R. Ta, R. Celli, and A. B. West, “Diffuse alveolar hemorrhage in systemic lupus erythematosus: histopathologic features and clinical correlations,” Case Reports in Pathology, vol. 2017, Article ID 1936282, 6 pages, 2017. View at Publisher · View at Google Scholar
  18. A. R. Lara and M. I. Schwarz, “Diffuse alveolar hemorrhage,” Chest, vol. 137, no. 5, pp. 1164–1171, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. N. M. Kazzaz, P. Coit, E. E. Lewis, W. J. McCune, A. H. Sawalha, and J. S. Knight, “Systemic lupus erythematosus complicated by diffuse alveolar haemorrhage: risk factors, therapy and survival,” Lupus Science & Medicine, vol. 2, no. 1, p. e000117, 2015. View at Publisher · View at Google Scholar · View at Scopus
  20. C. Ednalino, J. Yip, and S. E. Carsons, “Systematic review of diffuse alveolar hemorrhage in systemic lupus erythematosus: focus on outcome and therapy,” Journal of Clinical Rheumatology, vol. 21, no. 6, pp. 305–310, 2015. View at Publisher · View at Google Scholar · View at Scopus
  21. L. F. Pinto, C. J. Velásquez, C. Prieto, L. Mestra, E. Forero, and J. D. Márquez, “Rituximab induces a rapid and sustained remission in Colombian patients with severe and refractory systemic lupus erythematosus,” Lupus, vol. 20, no. 11, pp. 1219–1226, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Ramos-Casals, M. J. Soto, M. J. Cuadrado, and M. A. Khamashta, “Rituximab in systemic lupus erythematosus: a systematic review of off-label use in 188 cases,” Lupus, vol. 18, no. 9, pp. 767–776, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. P. P. Sfikakis, J. N. Boletis, S. Lionaki et al., “Remission of proliferative lupus nephritis following B cell depletion therapy is preceded by down-regulation of the T cell costimulatory molecule CD40 ligand: an open-label trial,” Arthritis & Rheumatism, vol. 52, no. 2, pp. 501–513, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. E. G. Kamburova, M. W. F. van den Hoogen, H. J. P. M. Koenen, M. C. Baas, L. B. Hilbrands, and I. Joosten, “Cytokine release after treatment with rituximab in renal transplant recipients,” Transplantation, vol. 99, no. 9, pp. 1907–1911, 2015. View at Publisher · View at Google Scholar · View at Scopus
  25. T. T. Barker, P. Y. Lee, K. M. Kelly-Scumpia et al., “Pathogenic role of B cells in the development of diffuse alveolar hemorrhage induced by pristane,” Laboratory Investigation, vol. 91, no. 10, pp. 1540–1550, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. H. Zhuang, S. Han, P. Y. Lee et al., “Pathogenesis of diffuse alveolar hemorrhage in murine lupus,” Arthritis & Rheumatology, vol. 69, no. 6, pp. 1280–1293, 2017. View at Publisher · View at Google Scholar