Case Report

Axial Spondyloarthritis and Autosomal Dominant Polycystic Kidney Disease in Two Siblings: A Rare Cooccurrence

Table 1

Clinical features, initial test results, and imaging results of patients.

Case 1Case 2

Age3730
GenderMaleFemale
Symptoms
Inflammatory back pain and 20 minutes of morning stiffnessInflammatory back pain, 2 hours of morning stiffness, and transient heel pain history
Laboratory findings
White blood cells (WBCs) (N: 4,100–11,000 cells/µL)6,7006,700
Neutrophils (N: 2,000–8,000 cells/µL)4,2404,510
Hemoglobin (Hgb) (N: 11–18 g/dL)13.0212.7
Hematocrit (HCT) (N: 35–55%)41.338.5
Platelets (PLTs) (N: 150,000–400,000 cells/µL)146,000208,000
C-reactive protein (CRP) (N ≤ 3.48 mg/dL)6.715.56
Erythrocyte sedimentation rate (ESR) (N: 0–20 mm/h)828
Serum creatinine (sCR) (N: 0.67–1.17 mg/dL)0.810.54
Aspartate transaminase (AST) (N: 0–50 U/L)16.919
Alanine transaminase (ALT) (N: 0–50 U/L)1911
Total urinalysis findings1.011 density (N: 1.015–1.020), and other parameters were normal1.020 density (N: 1.015–1.020), 10 erythrocytes, and 42 leukocytes
The Rose Bengal testNegativeNegative
Hepatitis B surface antigen (HBs-Ag)NegativeNegative
Anti-hepatitis C virus (HCV)NegativeNegative
Anti-human immunodeficiency virus (HIV)NegativeNegative
Human leukocyte antigen- (HLA-) B27NegativeNegative
Imaging
T1-weighted, fat-suppressed, gadolinium-enhanced MRI scan showed acute sacroiliitisPelvis anteroposterior radiograph showed right grade 3 sacroiliitis and left grade 2 sacroiliitis
MRI scan indicated old Romanus lesions and polycystic kidneysMRI scan indicated old Romanus lesions and polycystic kidneys