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Case Reports in Rheumatology
Volume 2018 (2018), Article ID 7657982, 4 pages
Case Report

Recurrent Migratory Transient Bone Marrow Edema of the Knees Associated with Low Vitamin D and Systemic Low Bone Mineral Density: A Case Report and Literature Review

Hamad Medical Corporation, Hamad General Hospital, Rheumatology Section, P.O. Box 3050, Doha, Qatar

Correspondence should be addressed to Omar Alsaed

Received 24 September 2017; Revised 10 January 2018; Accepted 24 January 2018; Published 18 February 2018

Academic Editor: Mehmet Soy

Copyright © 2018 Omar Alsaed and Mohammad Hammoudeh. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Transient bone marrow edema (TBME) is a self-limiting disease characterized by joint pain with localized bone marrow edema by MRI and has been reported in many case series and case reports. It is well known that joints of the lower extremity including hips, knees, ankles, and feet are the classical sites for TBME. Many theories have been proposed for the pathogenesis of TBME. Systemic osteopenia and vitamin D deficiency is one of the theories that have been suggested in the last few years. In this case report, we present a middle-aged male patient, who presented with 4 attacks of TBME in both knees between September 2016 and August 2017. The patient was found to have persistently low vitamin D and osteopenic T score in DXA scan of the lumbar spine and hips. Patients of TBME usually present with joint pain that is provoked by weight-bearing physical activity. The aim of this case report is to raise the awareness that TBME can be the initial presentation of systemic loss of bone mineral density.