Case Report

A Case of Multiple Myeloma Misdiagnosed as Seronegative Rheumatoid Arthritis and Review of Relevant Literature

Table 1

Literature review table.

Number of patientsAffected jointsSerologyMonoclonal gammopathy diagnosisReference

6Wrists and shoulders are the most commonly involved jointsFive patients were negative for RF and anti-CCP antibodies
One patient was positive for RF and anti-CCP antibodies
Four patients diagnosed with MGUS and two patients diagnosed with MMSrinivasulu [6]

2Wrists, hands, TMJ, and shouldersNegative RF
Negative anti-CCP
MM associated with amyloid arthropathyAlpay [7]

1Hands, wrists, shoulders, and kneesNegative RF
Anti-CCP antibodies were not reported
MMMolloy [8]

1Hands, knees, and feetNegative RF
Anti-CCP antibodies were not reported
MMArdalan [9]

9Hands, wrists, shoulders, and knees. One case had sacroiliitisNegative RF
Anti-CCP antibodies were not reported
Two patients diagnosed with MM. Seven patients diagnosed with MGUSJorgensen [10]

1DIP joints, PIP joints, wrists, knees, and anklesNegative RF
Negative anti-CCP antibodies
MM with amyloidosisRoca [11]

4DIP joints, PIP joints, MCP joints, and wristsNegative RF
Anti-CCP antibodies were not reported
MGUSVitali [12]

1KneesNegative RF
Negative anti-CCP antibodies
MMAgarwal [13]

1Hands and wristsNegative RF
Anti-CCP antibodies were not reported
MM with amyloidosisFujishima [14]

1Hands and wristsPositive anti-CCP antibodies
Negative RF
MMEdavalath [15]

43 of the 4 patients had polyarthritis of hands and wristsRF and anti-CCP antibodies were not reportedMM and amyloidosisBornstein [16]

RF: rheumatoid arthritis; anti-CCP antibodies: anti-cyclic citrullinated peptide antibodies.