The Central Nervous System Effects and Mimicry of Common Variable Immunodeficiency (CVID): A Case Report with Literature Review

Table 1

Case report MRI findings, treatment, and outcome.

Author	MRI findings	Treatment	Outcome
Farshad et al.	Spine: hyperintensity in the thoracic cord	Chronic glucocorticoids without pulse	Improvement in MRI findings
	Brain: hyperintensity within the right middle frontal gyrus	Methotrexate	Persistent neurological symptoms
		IVIG
Jabbari et al. [2]	Spine: hyperintensity between T2 and conus medullaris with contrast enhancement	Pulse glucocorticoids without a taper/chronic glucocorticoids	Improvement in MRI findings
	Brain: unremarkable	IVIG	Resolution of neurological symptoms
		Inpatient rehabilitation
Kumar et al. [3]	Spine: hyperintensity in the cervical and thoracic cord with contrast enhancement	Pulse glucocorticoids followed by chronic taper	Improvement in MRI findings
	Brain: contrast enhancement in the right basal forebrain	Infliximab	Persistent neurological symptoms
		IVIG
Danieli et al. [4]	Spine: hyperintensity in the cervical and thoracic cord with contrast enhancement	Pulse glucocorticoids without a taper/chronic glucocorticoids	No new lesions in MRI after treatment, unclear if resolved
	Brain: unremarkable	IVIG	Persistent neurological symptoms
		Intramuscular immunoglobulin
Nguyen et al. [5]	Spine: was not obtained	Pulse glucocorticoids without a taper/chronic glucocorticoids	Improvement in MRI findings
	Brain: two enhancing lesions in left cerebellum as well as leptomeningeal enhancement	Rituximab	Improvement/near resolution of neurological symptoms
		IVIG