Clinical and Diagnostic Considerations for Atypical, Adult Onset Presentation of Chronic Recurrent Multifocal Osteomyelitis (CRMO)

Table 1

Diagnostic criteria of NBO/CRMO.

Major diagnostic criteria	Minor diagnostic criteria
1. Radiologically proven osteolytic/sclerotic bone lesion	A. Normal blood count and good general state of health
2. Multifocal bone lesions	B. CRP and ESR mildly to moderately elevated
3. Palmoplantar pustulosis (PPP) or psoriasis	C. Observation time longer than 6 months
4. Sterile bone biopsy with signs of inflammation and/or fibrosis, sclerosis	D. Hyperostosis
	E. Associated with other autoimmune diseases apart from PPP or psoriasis
	F. Grade I or II relatives with autoimmune or autoinflammatory disease or with NBO

Diagnostic criteria from Jansson et al. Diagnosis confirmed with 2 major criteria or 1 major and 3 minor criteria [14].