Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Surgery
Volume 2012, Article ID 175272, 3 pages
Case Report

Castleman's Disease: A Case Report of the Unicentric Type

1Department of General Surgery, La Princesa University Hospital, 62 Diego de Leon Street, 28006 Madrid, Spain
2Department of Radiology, La Princesa University Hospital, 62 Diego de Leon Street, 28006 Madrid, Spain

Received 29 April 2012; Accepted 14 August 2012

Academic Editors: D. E. Jaroszewski and J. M. Strzelczyk

Copyright © 2012 J. Gomez-Ramirez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Castleman's disease, or angiofollicular lymph node hyperplasia, is a relatively rare disorder characterized by the benign proliferation of lymphoid tissue related to the chronic human herpes virus 8 (HHV-8) infection and the human immunodeficiency virus (HIV). Two clinical entities have been described: a unicentric presentation with the disease confined to a single anatomic lymph node and a multicentric presentation characterized by generalized lymphadenopathy and a more aggressive clinical course. Also, three histopathological subtypes have been described: hyaline-vascular, plasma cell, and a mixed variant. Preoperative diagnosis of hyaline-vascular Castleman's disease is difficult, and the definitive result is based on postoperative pathological findings. The gold standard therapy is the complete surgical excision.