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Case Reports in Surgery
Volume 2012 (2012), Article ID 693547, 4 pages
Case Report

Primary Malignant Melanoma of the Gallbladder: A Case Report and Review of the Literature

1Department of General Surgery, Merkez Efendi State Hospital, 35630 Manisa, Turkey
2Department of General Surgery, Izmir University, Izmir, Turkey
3Department of Pathology, Merkez Efendi State Hospital, Manisa, Turkey

Received 11 August 2012; Accepted 25 September 2012

Academic Editors: D. Mantas, O. Olsha, M. Picchio, and M. Rangarajan

Copyright © 2012 Mehmet Fatih Haskaraca et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Malignant melanoma is characterized by the ability of diffuse metastases. Since the first report of an isolated malignant melanoma case of the gallbladder, it is already controversial whether isolated cases are metastatic or primary tumors. A 49-year-old woman appealed to the emergency unit because of abdominal pain. Ultrasonography revealed increased thickness of the gallbladder wall and a lesion with surrounding fluid sized 12 mm without acoustic shadow, which arose from the gallbladder wall and was consistent with a polyp. Histopathologic evaluation of the surgical specimen after laparoscopic cholecystectomy revealed malign epithelial tumor consisting of atypical cells with large eosinophilic cytoplasm and dense melanin pigment within the cytoplasm of the tumor cells. As no other focus was identified as a result of the evaluation, the patient was diagnosed with primary malignant melanoma of the gallbladder. In this paper, we aimed to define our treatment modality for a case with isolated malignant melanoma of the gallbladder.