Metachronous Colon Metastasis to the Thyroid: A Case Report and Literature Review

Table 1

Case number	Paper	Age/gender	Location	Staging (Duke)	Adjuvant therapy	Time to occurrence of thyroid metastasis (years)	Associated thyroid pathology or neoplasia	Other organs involvement	Treatment	Prognosis
1	Willis 1931 [4]	54 M	Right colon	III	No	4	No	Liver, kidneys, lungs	No	—
2	Sklaroof, 1954	73 F	Rectum	—	—	7	Colloid nodule	No	Prophylactic tracheostomy	two months after diagnosis while attempting tracheostomy.
3	Elliott and Frantz, 1960 [1]	56 F	Rectum	—	—	Synchronous	Hashimoto's thyroiditis	—	Total thyroidectomy and RND	3 months
4	Shimaoka et al. 1962 [2]	50 F	Sigmoid colon	—	—	4	No	Lungs	Complete thyroidectomy	—
5	Wychulis et al., 1964 [3]	37 F	Rectum	III	No	0.5	No	Lungs	Rt thyroidectomy and isthmectomy	3 months
6	B. Make et al., 1974	68 M	Sigmoid colon	—	—	4	—	Liver	Radiation	8 months
7	J. A. Thomson 1975	44 F	Right colon	—	5fu	4	No	Brain	Thyroidectomy	9 months since clinical signs
8	T. Ishida et al., 1982	34 M	Rectum	II	Chemo and immunotherapy for 10 months	2	—	Generalized metastasis	Total thyroidectomy	7 months
9	J. W. Lester Jr. et al., 1986	56 F	Colon	—	—	2.5	—	Liver, Lungs	—	—
10	C. Rigaud et al., 1987	68 F	Colon	—	Yes (no spec)	2	—	Yes	Thyroidectomy and chemotherapy	3 months
11	C. Rigaud et al., 1987	77 M	Rectum	—	Yes (no spec)	4	—	Yes	Thyroidectomy and chemotherapy	1 month
12	E. G. Cristallini et al., 1990	64 F	Colon	—	—	4	No	Liver	Thyroidectomy	>12 months
13	D. Nachtigal et al., 1992	69 F	Left colon	II	No	8	No	Lungs	Total thyroidectomy	8 months
14	Y. Shibutani et al., 1992	52 F	Sigmoid colon	IV	—	3	No	Lungs	Subtotal thyroidectomy	8 months
15	S. Kim et al. 1994	37 F	Colon	—	—	7	—	Lymph nodes, skin	—	>2 months
16	T. W. Mesko et al., 1996	59 F	Rectum	II	5fu, leucovorin, levamisole, rx.	2	No	Vertebrae, kidney	Right thyroidectomy and isthmectomy. Radiation to vertebrae	>36 months
17	P. Osin et al., 1996	70 F	Rectosigmoid colon	IV	—	Synchronous	Thyroid colloid nodule	Liver	Rt thyroid lobectomy and isthmectomy	—
18	S. Takashima et al., 1998	67 M	Rectum	—	—	2	Hashimoto's	—	—	—
19 table	C. H. Kim et al., 1999	68 F	Sigmoid colon	II	No	2	No	Lungs	Left lobe thyroidectomy, radiation	—
20	K. Kameyama et al., 2000	82 M	Sigmoid colon	III	—	2	Follicular adenoma	Peritoneum, liver, lungs, kidneys, bones.	No	Died of MOF 2 years after colectomy
21	M. De Ridder et al., 2001	75 F	Left colon	III	—	7	Hyperthyroidism	No	Total thyroidectomy radiation	Disease recurs 4 months later. Pts died 9 months after the thyroid recurrence
22	M. S. Boleas Aguirre et al., 2001	80 F	Colon	—	—	7	—	Larynx	—	—
23	K. Akimaru et al., 2002	67 M	Right colon	III	—	6	No	Brain, lungs	Chemotherapy	4 months
24	G. P. Perinu et al., 2003	43 M	Left colon	—	—	4	MNG	Liver	—	—
25	R. L. Witt, 2003	71 M	Colon	III	—	7	Hurthle cell neoplasia	Lungs, liver	Rt thyroid lobectomy and isthmectomy	—
26	Fujita et al., 2004 [5]	28 F	Rectum	IV	5FU, CISPLATIN	Synchronous	No	Lungs	Left thyroid lobectomy and modified neck dissection	6 months
27	O. Fadare et al., 2005	59 F	Sigmoid colon	IV	—	Synchronous (incidental finding)	Follicular neoplasia	Liver, peritoneum	Thyroidectomy, chemotherapy	>12 months
28 table	Phillips et al. 2005 [6]	81 F	Colon	III	—	2	No	No	Total thyroidectomy and laryngectomy	—
29	J. C. Youn et al., 2006	85 M	Right colon	IIIB	5FU, LEUKOVORIN	1.5	Hypothyroidism	—	Irinotecan and fluoropyrimidine	—
30	K. Kumamoto et al., 2006	66 F	Right colon	I-II	5FU, Leucovorin	3.5	hypothyroidism	Liver, lungs	Left lobe thyroidectomy and cervical lymph nodes dissection	—
31	W. C. Hanna et al., 2006	48 F	Distal colon	IV	Yes	Synchronous	No	Lungs	Rt thyroid lobectomy and isthmectomy	—
32	I. Cozzolino et al., 2010	60 M	Rectosigmoid colon	IV	FOLFOX-4 (8 cycles) After lung met FOLFIRI, FOLFIRI + cetuximab. Mitomycin C + capecitabine, zoledronic acid RX	6	None	Lungs, liver, bones	Radiation	>72 months
33 abs	K. Nakamura et al., 2011	58 F	Sigmoid colon	—	—	5	None	Lung	Subtotal thyroidectomy, FOLFOX and bevacizumab	—
34	Goatman et al. 2012	82 M	Rectum and cecum	—	Refused	5	Papillary	Lung	Thyroidectomy, left neck dissection	—
35	Our case	62 F	Sigmoid colon	III	5 FU, leucovorin, oxaliplatin	5	None	Lung	Thyroidectomy, lung lobectomy, and re-colectomy	>24 months