Primary Gliosarcoma of the Cerebellum in a Young Pregnant Woman: Management Challenges and Immunohistochemical Features

Table 1

Clinical characteristics of primary GS cases with a posterior cranial fossa localization reported in the literature.

Case	Age/gender; [Ref.]	Clinical presentation	MRI features	Macro-/microscopic anatomy
1	62/M; [14]	Ataxia, adiadocokinesia	Not reported	Firm tumor, with dural adhesion to the tentorium cerebelli
2	71/M; [11]	Ataxia	Multiple lesions; perifocal edema; homogenous enhancement after gadolinium injection; broad base in contact with the dura mater	Firm, hemispheric well-circumscribed tumor, adherent to the dura; the superficial portion appeared sharply demarcated from the adjacent cerebellar tissue, intralesional hemorrhage/necrosis.
3	80/M; [15]	Intracranial hypertension	Solid, homogeneously enhancing mass in the vermis and left cerebellar hemisphere; peritumoral edema causing mass effect and compression on the IV ventricle	Firm and pseudo-encapsulated lesion without attachment to pia or dura; marginal hemorrhage and intralesional necrosis
4	70/F; [12]	Intracranial hypertension	Cerebellar intra-axial lesion, with a smooth and slightly lobulated outer layer; minimal peritumoral edema; heterogeneous enhancement after gadolinium injection	Relatively well-circumscribed and firm mass with areas of necrosis and hemorrhage
5	68/M; [6]	Not reported	Not reported	Discrete lesion with GBM-like characteristics
6	11/F; [13]	Ataxia, intracranial hypertension	Irregularly enhancing lesion located in the cerebellar vermis but characterized by bilateral extension; homogenous enhancement after gadolinium injection	Firm lesions reaching the surface of the cerebellum; white, glistening with areas of hemorrhage and necrosis
7	57/M; [16]	Intracranial hypertension	Solid lesion, isointense to the brain parenchyma on T1WI, hyperintense on T2WI, peripheral homogeneous enhancement after gadolinium injection	Firm intra-axial lesion without attachment to the dura mater
8	71/F; [17]	Intracranial hypertension	Solid, homogeneously enhancing, hemorrhagic mass in the cerebellopontine cistern	Well-circumscribed mass with intralesional hemorrhage
9	33/F; [present case]	Intracranial hypertension	Homogenously enhancing cortical-subcortical lesion localized on the right cerebellar hemisphere, responsible for perilesional edema and characterized by evidence of dural infiltration	Well-circumscribed and firm mass; white, glistening, with intralesional evidence of necrosis