Case Reports in Surgery / 2019 / Article / Tab 1

Case Report

Primary Gliosarcoma of the Cerebellum in a Young Pregnant Woman: Management Challenges and Immunohistochemical Features

Table 1

Clinical characteristics of primary GS cases with a posterior cranial fossa localization reported in the literature.

Clinical presentationMRI featuresMacro-/microscopic anatomy

Ataxia, adiadocokinesiaNot reportedFirm tumor, with dural adhesion to the tentorium cerebelli
AtaxiaMultiple lesions; perifocal edema; homogenous enhancement after gadolinium injection; broad base in contact with the dura materFirm, hemispheric well-circumscribed tumor, adherent to the dura; the superficial portion appeared sharply demarcated from the adjacent cerebellar tissue, intralesional hemorrhage/necrosis.
Intracranial hypertensionSolid, homogeneously enhancing mass in the vermis and left cerebellar hemisphere; peritumoral edema causing mass effect and compression on the IV ventricleFirm and pseudo-encapsulated lesion without attachment to pia or dura; marginal hemorrhage and intralesional necrosis
Intracranial hypertensionCerebellar intra-axial lesion, with a smooth and slightly lobulated outer layer; minimal peritumoral edema; heterogeneous enhancement after gadolinium injectionRelatively well-circumscribed and firm mass with areas of necrosis and hemorrhage
Not reportedNot reportedDiscrete lesion with GBM-like characteristics
Ataxia, intracranial hypertensionIrregularly enhancing lesion located in the cerebellar vermis but characterized by bilateral extension; homogenous enhancement after gadolinium injectionFirm lesions reaching the surface of the cerebellum; white, glistening with areas of hemorrhage and necrosis
Intracranial hypertensionSolid lesion, isointense to the brain parenchyma on T1WI, hyperintense on T2WI, peripheral homogeneous enhancement after gadolinium injectionFirm intra-axial lesion without attachment to the dura mater
Intracranial hypertensionSolid, homogeneously enhancing, hemorrhagic mass in the cerebellopontine cisternWell-circumscribed mass with intralesional hemorrhage
[present case]
Intracranial hypertensionHomogenously enhancing cortical-subcortical lesion localized on the right cerebellar hemisphere, responsible for perilesional edema and characterized by evidence of dural infiltrationWell-circumscribed and firm mass; white, glistening, with intralesional evidence of necrosis

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