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Case Reports in Transplantation
Volume 2011, Article ID 370596, 4 pages
http://dx.doi.org/10.1155/2011/370596
Case Report

Pediatric Renal Transplantation in a Highly Sensitised Child—8 Years On

1Paediatric Renal Transplant Centre, The Children’s University Hospital, Temple Street, Dublin 1, Ireland
2Our Lady's Children's Hospital, Crumlin, Dublin 12, Ireland
3Renal Transplant Unit, Beaumont Hospital, Dublin 9, Ireland
4National Histocompatibility and Immunogenetics Services for Solid Organ Transplantation, Beaumont Hospital, Dublin 9, Ireland

Received 24 November 2011; Accepted 25 December 2011

Academic Editors: J. A. Kari and M. Sadeghi

Copyright © 2011 Catherine Quinlan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Patel and P. I. Terasaki, “Significance of the positive crossmatch test in kidney transplantation,” The New England Journal of Medicine, vol. 280, pp. 735–739, 1969. View at Google Scholar
  2. S. K. Takemoto, A. Zeevi, S. Feng et al., “National conference to assess antibody-mediated rejection in solid organ transplantation,” American Journal of Transplantation, vol. 4, pp. 1033–1041, 2004. View at Google Scholar
  3. S. C. Jordan, A. A. Vo, D. Tyan, C. C. Nast, and M. Toyoda, “Current approaches to treatment of antibody-mediated rejection,” Pediatric Transplantation, vol. 9, no. 3, pp. 408–415, 2005. View at Publisher · View at Google Scholar · View at PubMed
  4. M. D. Kazatchkine and S. V. Kaveri, “Immunomodulation of autoimmune and inflammatory diseases with intravenous immune globulin,” The New England Journal of Medicine, vol. 345, no. 10, pp. 747–755, 2001. View at Publisher · View at Google Scholar · View at PubMed
  5. S. C. Jordan, A. A. Vo, C. C. Nast, and D. Tyan, “Use of high-dose human intravenous immunoglobulin therapy in sensitized patients awaiting transplantation: the Cedars-Sinai experience,” Clinical Transplants, pp. 193–198, 2003. View at Google Scholar
  6. R. A. Montgomery and A. A. Zachary, “Transplanting patients with a positive donor-specific crossmatch: a single center's perspective,” Pediatric Transplantation, vol. 8, no. 6, pp. 535–542, 2004. View at Publisher · View at Google Scholar · View at PubMed
  7. R. L. Hanto, W. Reitsma, and F. L. Delmonico, “The development of a successful multiregional kidney paired donation program,” Transplantation, vol. 86, no. 12, pp. 1744–1748, 2008. View at Publisher · View at Google Scholar · View at PubMed
  8. S. C. Jordan, A. Vo, S. Bunnapradist et al., “Intravenous immune globulin treatment inhibits crossmatch positivity and allows for successful transplantation of incompatible organs in living-donor and cadaver recipients,” Transplantation, vol. 76, no. 4, pp. 631–636, 2003. View at Publisher · View at Google Scholar · View at PubMed
  9. M. D. Pescovitz, “The use of rituximab, anti-CD20 monoclonal antibody, in pediatric transplantation,” Pediatric Transplantation, vol. 8, no. 1, pp. 9–21, 2004. View at Publisher · View at Google Scholar · View at PubMed
  10. V. D. Garcia, J. L. Bonamigo Filho, J. Neumann et al., “Rituximab in association with rapamycin for post-transplant lymphoproliferative disease treatment,” Transplant International, vol. 16, no. 3, pp. 202–206, 2003. View at Publisher · View at Google Scholar
  11. K. Nozu, K. Iijima, M. Fujisawa, A. Nakagawa, N. Yoshikawa, and M. Matsuo, “Rituximab treatment for posttransplant lymphoproliferative disorder (PTLD) induces complete remission of recurrent nephrotic syndrome,” Pediatric Nephrology, vol. 20, no. 11, pp. 1660–1663, 2005. View at Publisher · View at Google Scholar · View at PubMed
  12. D. G. Maloney, T. M. Liles, D. K. Czerwinski et al., “Phase I clinical trial using escalating single-dose infusion of chimeric anti-CD20 monoclonal antibody (IDEC-C2B8) in patients with recurrent B-cell lymphoma,” Blood, vol. 84, no. 8, pp. 2457–2466, 1994. View at Google Scholar
  13. M. E. Reff, K. Carner, K. S. Chambers et al., “Depletion of B cells in vivo by a chimeric mouse human monoclonal antibody to CD20,” Blood, vol. 83, no. 2, pp. 435–445, 1994. View at Google Scholar
  14. J. Rodriguez and A. Gutierrez, “Pharmacokinetic properties of rituximab,” Reviews on Recent Clinical Trials, vol. 3, no. 1, pp. 22–30, 2008. View at Publisher · View at Google Scholar
  15. C. A. Vieira, A. Agarwal, B. K. Book et al., “Rituximab for reduction of anti-HLA antibodies in patients awaiting renal transplantation: 1. Safety, pharmacodynamics, and pharmacokinetics,” Transplantation, vol. 77, no. 4, pp. 542–548, 2004. View at Publisher · View at Google Scholar
  16. K. E. Papez and W. E. Smoyer, “Recent advances in congenital nephrotic syndrome,” Current Opinion in Pediatrics, vol. 16, no. 2, pp. 165–170, 2004. View at Publisher · View at Google Scholar
  17. P. Gailiunas Jr., M Suthanthiran, G. J. Busch, C. B. Carpenter, and M. R. Garovoy, “Role of humoral presenitization in human renal transplant rejection,” Kidney International, vol. 17, pp. 638–646, 1980. View at Google Scholar
  18. A. Soosay, D. O'Neill, A. Counihan, D. Hickey, and M. Keogan, “Causes of sensitisation in patients awaiting renal transplantation in Ireland,” Irish Medical Journal, vol. 96, no. 4, pp. 109–112, 2003. View at Google Scholar · View at Scopus
  19. H. M. Gebel, R. A. Bray, and P. Nickerson, “Pre-transplant assessment of donor-reactive, HLA-specific antibodies in renal transplantation: contraindication vs. risk,” American Journal of Transplantation, vol. 3, no. 12, pp. 1488–1500, 2003. View at Publisher · View at Google Scholar · View at Scopus
  20. A. L. Girnita, S. A. Webber, and A. Zeevi, “Anti-HLA alloantibodies in pediatric solid organ transplantation,” Pediatric Transplantation, vol. 10, no. 2, pp. 146–153, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  21. D. Glotz, C. Antoine, and A. Duboust, “Antidonor antibodies and transplantation: how to deal with them before and after transplantation,” Transplantation, vol. 79, no. 3, pp. S30–S32, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. M. P. Emonds, J. Herman, J. Dendievel, M. Waer, and R. van Damme-Lombaerts, “Evaluation of anti-human leukocyte antigen allo-immunization in pediatric cadaveric kidney transplantation,” Pediatric Transplantation, vol. 4, no. 1, pp. 6–11, 2000. View at Publisher · View at Google Scholar · View at Scopus
  23. R. E. Shaddy and T. C. Fuller, “The sensitized pediatric heart transplant candidate: causes, consequences, and treatment options,” Pediatric Transplantation, vol. 9, no. 2, pp. 208–214, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  24. C. C. Magee, “Transplantation across previously incompatible immunological barriers,” Transplant International, vol. 19, no. 2, pp. 87–97, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  25. F. H. Claas, M. D. Witvliet, R. J. Duquesnoy, G. G. Persijn, and I. I. Doxiadis, “The acceptable mismatch program as a fast tool for highly sensitized patients awaiting a cadaveric kidney transplantation: short waiting time and excellent graft outcome,” Transplantation, vol. 78, no. 2, pp. 190–193, 2004. View at Google Scholar · View at Scopus
  26. I. I. N. Doxiadis, J. M. A. Smits, G. G. Persijn, U. Frei, and F. H. J. Claas, “It takes six to boogie: allocating cadaver kidneys in Eurotransplant,” Transplantation, vol. 77, no. 4, pp. 615–617, 2004. View at Publisher · View at Google Scholar · View at Scopus
  27. M. De Klerk, K. M. Keizer, F. H. J. Claas, M. Witvliet, B. J. J. M. Haase-Kromwijk, and W. Weimar, “The Dutch national living donor kidney exchange program,” American Journal of Transplantation, vol. 5, no. 9, pp. 2302–2305, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  28. I. Kaplan, J. A. Houp, R. A. Montgomery, M. S. Leffell, J. M. Hart, and A. A. Zachary, “A computer match program for paired and unconventional kidney exchanges,” American Journal of Transplantation, vol. 5, pp. 2306–2308, 2005. View at Google Scholar
  29. F. L. Delmonico, P. E. Morrissey, G. S. Lipkowitz et al., “Donor kidney exchanges,” American Journal of Transplantation, vol. 4, no. 10, pp. 1628–1634, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  30. S. C. Jordan, A. W. Quartel, L. S. C. Czer et al., “Posttransplant therapy using high-dose human immunoglobulin (intravenous gammaglobulin) to control acute humoral reaction in renal and cardiac allograft recipients and potential mechanism of action,” Transplantation, vol. 66, no. 6, pp. 800–808, 1998. View at Publisher · View at Google Scholar · View at Scopus
  31. S. C. Jordan, A. Vo, D. Tyan, and M. Toyota, “Desensitization therapy with intravenous gammaglobulin (IVIG): applications in solid organ transplantation,” Trans Am Clin Climatol Assoc, vol. 117, pp. 199–211, 2006, discussion p. 211. View at Google Scholar
  32. S. C. Jordan, D. Tyan, D. Stablein et al., “Evaluation of intravenous immunoglobulin as an agent to lower allosensitization and improve transplantation in highly sensitized adult patients with end-stage renal disease: report of the NIH IG02 trial,” Journal of the American Society of Nephrology, vol. 15, no. 12, pp. 3256–3262, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  33. T. J. Kroshus, A. P. Dalmasso, J. R. Leventhal, R. John, A. J. Matas, and R. M. Bolman III, “Antibody removal by column immunoabsorption prevents tissue injury in an ex vivo model of pig-to-human xenograft hyperacute rejection,” Journal of Surgical Research, vol. 59, no. 1, pp. 43–50, 1995. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  34. T. Sawada, S. Fuchinoue, T. Kawase, K. Kubota, and S. Teraoka, “Preconditioning regimen consisting of anti-CD20 monoclonal antibody infusions, splenectomy and DFPP-enabled non-responders to undergo ABO-incompatible kidney transplantation,” Clinical Transplantation, vol. 18, no. 3, pp. 254–260, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  35. Y. Yamazaki, H. Kawaguchi, K. Ito, K. Takahashi, H. Toma, and K. Ota, “ABO incompatible kidney transplantation in children,” Journal of Urology, vol. 154, no. 2, pp. 914–916, 1995. View at Publisher · View at Google Scholar · View at Scopus
  36. E. Berglin, C. Kjellstrom, V. Mantovani, G. Stelin, C. Svalander, and L. Wiklund, “Plasmapheresis as a rescue therapy to resolve cardiac rejection with vasculitis and severe heart failure: a report of five cases,” Transplant International, vol. 8, no. 5, pp. 382–387, 1995. View at Publisher · View at Google Scholar · View at Scopus
  37. P. Fauchald, T. Leivestad, D. Albrechtsen, Y. Willassen, A. Jacobsen, and A. Flatmark, “Plasma exchange and immunoadsorption prior to renal transplantation in allosensitized patients,” Transplantation Proceedings, vol. 22, no. 1, pp. 149–150, 1990. View at Google Scholar · View at Scopus
  38. D. L. Segev, C. E. Simpkins, D. S. Warren et al., “ABO incompatible high-titer renal transplantation without splenectomy or anti-CD20 treatment,” American Journal of Transplantation, vol. 5, no. 10, pp. 2570–2575, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  39. R. Ben-Youssef, Y. Iwaki, P. Baron et al., “Successful living related kidney transplantation across an anti-donor HLA antibody,” Transplantation Proceedings, vol. 38, no. 5, pp. 1280–1282, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  40. A. V. Reisaeter, T. Leivestad, D. Albrechtsen et al., “Pretransplant plasma exchange or immunoadsorption facilitates renal transplantation in immunized patients,” Transplantation, vol. 60, no. 3, pp. 242–248, 1995. View at Google Scholar · View at Scopus