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Case Reports in Transplantation
Volume 2013, Article ID 146347, 4 pages
http://dx.doi.org/10.1155/2013/146347
Case Report

Therapeutic Potential of Umbilical Cord Mesenchymal Stromal Cells Transplantation for Cerebral Palsy: A Case Report

1Cell Therapy Center, 323 Hospital of People's Liberation Army, Xi'an 710054, China
2Alliancells Institute of Stem Cells and Translational Regenerative Medicine & Alliancells Bioscience Co., Ltd., Tianjin 300381, China
3Zhongyuan Union Stem Cell Bioengineering Stock Company, Tianjin 300050, China
4Beijing Alliancells-PuRui Bioscience Co., Ltd., Beijing 100052, China
5Department of Cell Biology, Oklahoma State University, Tulsa, OK 74106, USA
6Harold Hamm Oklahoma Diabetes Center and Section of Endocrinology and Diabetes in the Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA

Received 24 January 2013; Accepted 13 February 2013

Academic Editors: M. Ferraresso, J. Jazbec, and M. Sadeghi

Copyright © 2013 Liming Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cerebral palsy is the most common motor disability in childhood. In current paper, we first report our clinical data regarding administration of umbilical cord mesenchymal stem cells (MSCs) transplantation in treatment of cerebral palsy. A 5-year-old girl with cerebral palsy was treated with multiple times of intravenous and intrathecal administration of MSCs derived from her young sister and was followed up for 28 months. The gross motor dysfunction was improved. Other benefits included enhanced immunity, increased physical strength, and adjusted speech and comprehension. Temporary low-grade fever was the only side effect during the treatment. MSCs may be a safe and effective therapy to improve symptoms in children with cerebral palsy.