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Case Reports in Transplantation
Volume 2013 (2013), Article ID 397087, 3 pages
http://dx.doi.org/10.1155/2013/397087
Case Report

Tuberous Sclerosis Associated with Polycystic Kidney Disease: Effects of Rapamycin after Renal Transplantation

1Service of Nephrology, University Hospital of Salamanca, Paseo de San Vicente 58-182, 37007 Salamanca, Spain
2Service of Neurology, Public Hospital of Cotentin, Rue Trottebec, 50100 Cherbourg-Octeville, France

Received 19 November 2012; Accepted 30 December 2012

Academic Editors: M. G. H. Betjes, I. Engelmann, S. Faenza, and R. Grenda

Copyright © 2013 C. Rosado et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Tuberous sclerosis is rarely associated with autosomal dominant polycystic kidney disease in the so-called tuberous sclerosis complex. This association leads to an increased frequency of end-stage renal disease. We present a patient suffering from both syndromes, who received a renal graft and anticalcineurinic drugs as immunosuppressive agents. Progressive titration of the drug was necessary in order to attain the effective doses due to the enzymatic induction caused by concomitant treatment with antiepileptic drugs. These high doses resulted in nephrotoxicity. Immunosuppressor treatment was switched to rapamycin, whereby an improvement in renal function and other signs of tuberous sclerosis and polycystic kidney disease was observed. This case report highlights both the efficacy and safety of rapamycin as an immunosuppressor treatment and its capacity for controlling other symptoms of these genetic-related disorders.