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Case Reports in Transplantation
Volume 2013 (2013), Article ID 951827, 6 pages
http://dx.doi.org/10.1155/2013/951827
Case Report

First Autologous Cell Therapy of Cerebral Palsy Caused by Hypoxic-Ischemic Brain Damage in a Child after Cardiac Arrest—Individual Treatment with Cord Blood

1Campus Clinic Gynecology, Ruhr-University Bochum, Universitätsstrasse 140, 44799 Bochum, Germany
2Department of Pediatrics, Ruhr-University Bochum, St. Josef-Hospital, Alexandrinenstrasse 5, 44791 Bochum, Germany

Received 11 March 2013; Accepted 18 April 2013

Academic Editors: M. Doshi and M. R. Moosa

Copyright © 2013 A. Jensen and E. Hamelmann. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Video S1: Brain MRI (FLAIR sequences). Brain MRI (FLAIR sequences) of a 2.5 years old patient (L.B.) 14 days after global hypoxic-ischemic insult caused by cardiac arrest. Note, massive damage as evidenced by signal hyperintensity in almost the entire cortex and basal ganglia.

Video S2: Brain MRI (FLAIR DWI sequences with contrast media). Brain MRI (FLAIR DWI sequences with contrast media) of a 2.5 years old patient (L.B.) 14 days after global hypoxic-ischemic insult caused by cardiac arrest. Note, massive damage as evidenced by signal hyperintensity in basal ganglia, caudate nucleus, putamen and particularly in the pallidum.

Video S3: Neurologic examination before transplantation. Neurologic examination of the patient (L.B.) in a persistent vegetative state before transplantation of cord blood cells. Note, severe cerebral palsy (tetraspastic ) 9 weeks after global hypoxic-ischemic insult caused by cardiac arrest. Note also, there is no motor control of the head.

Video S4: Functional neuroregeneration at two months follow-up. Functional neuroregeneration at two months follow-up after transplantation of cord blood cells. Note, the social smiling and response when the patient (L.B.) is addressed, independent eating of a biscuit, improved motor control of the head, recovered eyesight and hearing.

Video S5: Functional neuroregeneration at two years follow-up (a). Functional neuroregeneration at two years follow-up after transplantation of cord blood cells. The patient (L.B.) walks independently in a gait trainer, improved understanding and speaking in response to questions. Note, broad understanding of spoken context.

Video S6: Functional neuroregeneration at two years follow-up (b). Functional neuroregeneration at two years follow-up after transplantation of cord blood cells. The patient (L.B.) is steering a remote control car by console with much improved fine motor control in both hands and fingers. Note, the patient moves from prone to free sitting position.

  1. Supplementary Materials