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Case Reports in Transplantation
Volume 2013, Article ID 978481, 5 pages
Case Report

De Novo Fibrillary Glomerulonephritis (FGN) in a Renal Transplant with Chronic Hepatitis C

1Department of Medicine, Thomas Jefferson University, 2228 South Broad Street, Philadelphia, PA 19145, USA
2Division of Nephrology, Thomas Jefferson University, Philadelphia, PA 19107, USA
3Department of Pathology, Thomas Jefferson University, Philadelphia, PA 19107, USA

Received 8 May 2013; Accepted 5 June 2013

Academic Editors: P. A. Andrews, M. L. Coppage, R. L. Heilman, F. Keller, and S. Pinney

Copyright © 2013 Edward J. Filippone et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Chronic hepatitis C viremia (HepC) has been associated with numerous renal manifestations both in native kidneys and in the setting of renal transplantation. Glomerulonephritis (GN) of the renal allograft in the setting of HepC most commonly manifests as type 1 membranoproliferative GN (MPGN), either representing recurrence of the original disease or arising de novo. Other GNs were reported after transplantation in the patient with HepC including membranous nephropathy and thrombotic microangiopathy, as well as an enhanced susceptibility to transplant glomerulopathy. We describe the first case of de novo fibrillary GN in a renal transplant patient with HepC where the primary renal disease was biopsy proven type 1 MPGN. We discuss this relationship in detail.