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Case Reports in Transplantation
Volume 2014, Article ID 160407, 3 pages
Case Report

Leukocytoclastic Vasculitis as a Complication of Recombinant Granulocyte Colony-Stimulating Factor Therapy in a Heart Transplant Patient

1U.O Medicina Interna, Policlinico di Monza, Via C. Amati 111, 20900 Monza, Italy
2Division of Cardiac Surgery, University of Pavia School of Medicine, Foundation “I.R.C.C.S. San Matteo” Hospital, Pavia, Italy
3Anatomic Pathology, Foundation IRCCS Policlinico San Matteo, University of Pavia, Italy

Received 18 September 2013; Accepted 16 December 2013; Published 30 January 2014

Academic Editors: F. Meloni and M. Sadeghi

Copyright © 2014 Giovanbattista Ippoliti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Recombinant granulocyte colony-stimulating factor (rG-CSF) is a myeloid growth factor that is widely used in haematology to recover neutropenia secondary to myelosuppressive chemotherapy. Leukocytoclastic vasculitis is an acknowledged side effect of the above therapy. Its pathogenesis involves many mechanisms that collectively induce an increase in neutrophil function and a subsequent release of cytokines. Here, we report a case of leukocytoclastic vasculitis proven by skin biopsy, following the use of rG-CSF in a heart transplant patient with leukopenia secondary to immunosuppressive therapy.