Drug-Induced Liver Injury Associated with the Use of Everolimus in a Liver Transplant Patient
Table 1
Adverse drug reaction probability scale (Naranjo) [17].
Question
Yes
No
Do Not Know
Score
1. Are there previous conclusive reports on this reaction?
+1
0
0
0
2. Did the adverse event appear after the suspected drug was administered?
+2
-1
0
+2
3. Did the adverse event improve when the drug was discontinued or a specific antagonist was administered?
+1
0
0
+1
4. Did the adverse event reappear when the drug was readministered?
+2
-1
0
0
5. Are there alternative causes that could on their own have caused the reaction? (alternatives have been excluded =no)
-1
+2
0
+2
6. Did the reaction reappear when a placebo was given?
-1
+1
0
0
7. Was the drug detected in blood or other fluids in concentrations known to be toxic?
+1
0
0
0
8. Was the reaction more severe when the dose was increased or less severe when the dose was decreased? (reaction was less severe when the dose was decreased)
+1
0
0
+1
9. Did the patient have a similar reaction to the same or similar drugs in any previous exposure?
+1
0
0
0
10. Was the adverse event confirmed by any objective evidence?
