Absence of Rejection in a Facial Allograft Recipient with a Positive Flow Crossmatch 24 Months after Induction with Rabbit Anti-Thymocyte Globulin and Anti-CD20 Monoclonal Antibody
Table 2
Timeline and findings of skin biopsies performed after facial allotransplantation.
Post-operative day (POD)
Histopathological Findings
Banff Grade
Clinical Presentation
POD 3
Sparse perivascular mononuclear cell infiltrate; no rejection
0
Planned biopsy; no clinical signs or symptoms.
POD 95
Superficial perivascular lymphocytic infiltrate; no rejection
0
Mild facial swelling and erythema resolved after administration of diphenhydramine; presumed allergic response.
POD 171
Sparse perivascular lymphocytic infiltrate with rare eosinophils; no rejection
0
Planned biopsy prior to outpatient surgery; no clinical signs or symptoms.
POD 410
Sparse superficial perivascular dermatitis with eosinophils; “early rejection cannot be excluded” but likely drug eruption
