Von Hippel-Lindau Syndrome: Diagnosis and Management of Hemangioblastoma and Pheochromocytoma

Figure 3

The lobulated hypercellular tumor is composed of large, polygonal cells with a low nuclear/cytoplasmic ratio and a grainy basophilic cytoplasm. The tumor is encircled by cells that form the cortical region of the adrenal gland. The mass is well demarcated, with no capsule or pseudocapsule.