Amiodarone Induced Hyponatremia Masquerading as Syndrome of Inappropriate Antidiuretic Hormone Secretion by Anaplastic Carcinoma of Prostate

Figure 3

((a) and (b)) Microphotograph from the prostate shows a tumor present in sheets with hyperchromatic nuclei and scanty cytoplasm consistent with morphology of small cell carcinoma H&E ×200. Insets show (a) tumor cells at high power which show moulding H&E ×400 and (b) strong positivity with neurone specific enolase IHC ×100. (c) Immunohistochemistry showing vasopressin negativity. (d) Immunohistochemistry for the carrier protein neurophysin is negative. (e) Immunohistochemistry for prostate specific antigen (PSA) is conspicuously negative suggestive of dedifferentiated tumor.