Case Reports in Urology / 2014 / Article / Tab 1

Case Report

Amiodarone Induced Hyponatremia Masquerading as Syndrome of Inappropriate Antidiuretic Hormone Secretion by Anaplastic Carcinoma of Prostate

Table 1

Summary of cases of SIADH Induced by amiodarone, including the present case.

Serial numberAuthor and yearAgeGenderSodium level at diagnosis
(mmol/L)
Amiodarone dose and durationTime to develop hyponatremiaManagementDay on which serum sodium normalized

1 Ruiz et al. 1996 [8] 67F110Not mentioned4 MonthsDiscontinuationUnknown
2 Odeh et al. 1999 [7]62F120300 mg qd6 MonthsDiscontinuation 5 Days
3 Patel and Kasiar 2002 [9] 67M117200 mg qd3 MonthsFluid restriction, Discontinuation of therapy3 Days
4 Ikegami et al. 2002 [11] 63M119800 mg qd7 Days Amiodarone dose reduced to 100 mg qd, fluid restriction28 days
5 Ikegami et al. 2002 [11] 87M121200 mg qd for seven days then 100 mg qd15 DaysFluid restriction only14 Days
6 Aslam et al. 2004 [10] 72M1172 g qd (loading dose)5 DaysDecrease dose to 200 mg qdNormalized on 2nd day, Stable on 14th day
7 Paydas et al. 2008 [12] 58M107Not mentioned5 MonthsCessation of treatment14 Days
8 Shavit and sherer 2007 [13] 85M122Not mentioned30 DaysCessation of treatmentA few days, stable at 3rd month
9 Singla et al. 2013 [14] 66M120Loading followed by 400 mg four times a day 3 DaysDiscontinuation of amiodarone and hemodialysisNot Mentioned
10 Afshinnia et al. 2011 [15] 72M117150 mg IV loading, 900 mg over 24 hours, 400 mg TDS7 days16 Days
11 Pham et al. 2013 [16] 84M105Loading followed by 400 mg 8 hourly ×3 days. Then 400 mg OD11 DaysHypertonic saline, Fluid restriction, Demichlocycline,10 Days
12Dutta et al. (Present Case) 62M109100 mg OD9 MonthsFluid restriction, stoppage of amiodarone3 Days

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