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Case Reports in Urology
Volume 2015 (2015), Article ID 523258, 4 pages
Case Report

28-Year Survival following Several Metastasectomies, Going through 8th Line Systemic Therapy in a Case of mRCC

Universitätsklinikum Salzburger Landeskrankenhaus (SALK), 5020 Salzburg, Austria

Received 15 October 2014; Accepted 11 February 2015

Academic Editor: Apul Goel

Copyright © 2015 A. Magdy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Metastatic renal cell carcinoma (mRCC) has been one of the most treatment-resistant cancers because of its unpredictable clinical course, resistance to chemo- and radiotherapy, and the limited response to immunotherapy and targeted agents. We present a case of long-term survival, that is, 28 years, after primary diagnosis (longest survival in the literature up to our knowledge) with mRCC after several metastasectomies (from local site recurrence, liver, and lung) and eight lines of systemic targeted therapy. This case report shows how crucial is the regular follow-up of patients with RCC after primary management and positive impact of early metastasectomy and systemic targeted therapy in case of mRCC on patients’ condition and overall survival.