Case Reports in Urology / 2019 / Article / Tab 1

Case Report

A Fatal Case of Life-Threatening Interstitial Pneumonitis Induced by Everolimus for Metastatic Renal Cell Carcinoma: A Comment about the Increased Risk of Interstitial Lung Disease in Japanese

Table 1

Comparison of previous studies regarding interstitial lung disease associated with TKI or mTOR inhibitor in Japanese patients with renal cell carcinoma and lung cancer.

% of ILD
SeriesType of cancerType of drugnAll gradesGrade 3/4Grade 5

Mizuno et al. [3]RCCmTOR inhibitor (Everolimus)1163.636.30
Mikami et al. [14]RCCmTOR inhibitor (Everolimus)163100
Akamatsu et al. [15]NSCLCTKI (Gefetinib)20152.51
Nakagawa et al. [16]NSCLCTKI (Erlotinib)34884.52.61.6
Ando et al. [13]NSCLCTKI (Gefetinib)19763.51.91.6

RCC, renal cell carcinoma; NSCLC, nonsmall cell lung carcinoma; ILD, interstitial lung disease; mTOR, mammalian target of rapamycin; TKI, tyrosine kinase inhibitor.