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Case Reports in Veterinary Medicine
Volume 2013, Article ID 167923, 4 pages
Case Report

Apocrine Sweat Gland Ductal Adenoma with Sebaceous Differentiation in a Dog

Department of Veterinary Pathology, Nippon Veterinary and Life Science University, 1-7-1 Musashino, Kyounan-cho, Tokyo 180-8602, Japan

Received 12 November 2013; Accepted 28 November 2013

Academic Editors: N.-Y. Park and R. L. Santos

Copyright © 2013 Masaki Michishita et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A 7-year-old male, Border Collie, developed a firm mass, measuring approximately 1 cm in diameter, in the left buccal skin. Histologically, the mass was composed of ductal structures lined by bilayered luminal epithelial and basaloid tumor cells along with a few nests of sebaceous cells. Immunohistochemical staining revealed that the luminal epithelial tumor cells were positive for cytokeratin (CK, CAM5.2) and CK19 but not for CK14 or p63. In contrast, the basaloid tumor cells were positive for CK14, p63, and αSMA but not for CK19 or CAM5.2. CK8 expression was observed in both luminal epithelial and basaloid tumor cells. The tumor cells with sebaceous differentiation were positive for CK14 but not for the other markers. This is the first case of an apocrine sweat gland ductal adenoma with sebaceous differentiation occurring in the buccal skin of a dog.